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Olr59 olfactory receptor 59 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170816, updated on 5-Jan-2022

Summary

Official Symbol
Olr59provided by RGD
Official Full Name
olfactory receptor 59provided by RGD
Primary source
RGD:628858
See related
Ensembl:ENSRNOG00000018606
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RA1c; Olfr78; Or51e2
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Liver (RPKM 32.2), Kidney (RPKM 11.6) and 6 other tissues See more
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Genomic context

See Olr59 in Genome Data Viewer
Location:
1q32
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (157193051..157227707, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167906030..167940688, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 60 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene olfactory receptor pseudogene 58 Neighboring gene olfactory receptor 57 Neighboring gene olfactory receptor 56 Neighboring gene olfactory receptor pseudogene 55

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables olfactory receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables steroid hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables steroid hormone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in melanocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in melanocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in melanocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in melanocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of renin secretion into blood stream IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of renin secretion into blood stream ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of renin secretion into blood stream ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid hormone mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
olfactory receptor 51E2
Names
G-protein coupled receptor RA1c
olfactory receptor 78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173293.2NP_775415.2  olfactory receptor 51E2

    Status: REVIEWED

    Source sequence(s)
    JACYVU010000042
    Related
    ENSRNOP00000092126.1, ENSRNOT00000115264.1
    Conserved Domains (1) summary
    cd15222
    Location:24298
    7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    157193051..157227707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759671.1XP_008757893.1  olfactory receptor 51E2 isoform X1

    See identical proteins and their annotated locations for XP_008757893.1

    UniProtKB/TrEMBL
    G3V8E6
    Conserved Domains (1) summary
    cd15222
    Location:24298
    7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_008759669.3XP_008757891.1  olfactory receptor 51E2 isoform X1

    See identical proteins and their annotated locations for XP_008757891.1

    UniProtKB/TrEMBL
    G3V8E6
    Related
    ENSRNOP00000025097.2, ENSRNOT00000025097.6
    Conserved Domains (1) summary
    cd15222
    Location:24298
    7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_008759670.3XP_008757892.1  olfactory receptor 51E2 isoform X1

    See identical proteins and their annotated locations for XP_008757892.1

    UniProtKB/TrEMBL
    G3V8E6
    Conserved Domains (1) summary
    cd15222
    Location:24298
    7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
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