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Acot8 acyl-CoA thioesterase 8 [ Mus musculus (house mouse) ]

Gene ID: 170789, updated on 8-Feb-2024

Summary

Official Symbol
Acot8provided by MGI
Official Full Name
acyl-CoA thioesterase 8provided by MGI
Primary source
MGI:MGI:2158201
See related
Ensembl:ENSMUSG00000017307 AllianceGenome:MGI:2158201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pte1; PTE-1; PTE-2
Summary
Enables acyl-CoA hydrolase activity. Acts upstream of or within acyl-CoA metabolic process. Located in peroxisome. Orthologous to human ACOT8 (acyl-CoA thioesterase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 26.5), duodenum adult (RPKM 22.8) and 28 other tissues See more
Orthologs
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Genomic context

See Acot8 in Genome Data Viewer
Location:
2 H3; 2 85.27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164634688..164662132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164792768..164820219, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast Neighboring gene sorting nexin family member 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164630130-164630494 Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene STARR-seq mESC enhancer starr_06336 Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene spermatogenesis associated 25

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetoacetyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables choloyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxymethylglutaryl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables medium-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables succinyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dicarboxylic acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of CD4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peroxisome organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 8
Names
choloyl-coenzyme A thioesterase
peroxisomal acyl-CoA thioesterase 1
peroxisomal acyl-CoA thioesterase 2
peroxisomal acyl-coenzyme A thioester hydrolase 1
peroxisomal long-chain acyl-CoA thioesterase 1
NP_001349685.1
NP_001349686.1
NP_573503.2
XP_006498892.1
XP_006498894.1
XP_011237620.1
XP_011237621.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362756.1NP_001349685.1  acyl-coenzyme A thioesterase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK033724, AL591127
    Consensus CDS
    CCDS89580.1
    UniProtKB/TrEMBL
    Q8BZR4
    Related
    ENSMUSP00000017451.7, ENSMUST00000017451.7
    Conserved Domains (1) summary
    cl26120
    Location:35246
    4HBT_3; Thioesterase-like superfamily
  2. NM_001362757.1NP_001349686.1  acyl-coenzyme A thioesterase 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL591127
    Conserved Domains (1) summary
    TIGR00189
    Location:3228
    tesB; acyl-CoA thioesterase II
  3. NM_133240.2NP_573503.2  acyl-coenzyme A thioesterase 8 isoform 1

    See identical proteins and their annotated locations for NP_573503.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI122325, AK151924, BB604985
    Consensus CDS
    CCDS17057.1
    UniProtKB/Swiss-Prot
    P58137, Q8VHM4
    UniProtKB/TrEMBL
    Q3U965
    Related
    ENSMUSP00000099383.5, ENSMUST00000103094.11
    Conserved Domains (3) summary
    cd03444
    Location:206309
    Thioesterase_II_repeat1; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...
    cd03445
    Location:40131
    Thioesterase_II_repeat2; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...
    TIGR00189
    Location:35310
    tesB; acyl-CoA thioesterase II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164634688..164662132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498831.5XP_006498894.1  acyl-coenzyme A thioesterase 8 isoform X4

    Conserved Domains (1) summary
    TIGR00189
    Location:2179
    tesB; acyl-CoA thioesterase II
  2. XM_006498829.2XP_006498892.1  acyl-coenzyme A thioesterase 8 isoform X2

    Conserved Domains (1) summary
    TIGR00189
    Location:3227
    tesB; acyl-CoA thioesterase II
  3. XM_011239318.4XP_011237620.1  acyl-coenzyme A thioesterase 8 isoform X1

    Conserved Domains (1) summary
    TIGR00189
    Location:9230
    tesB; acyl-CoA thioesterase II
  4. XM_011239319.2XP_011237621.1  acyl-coenzyme A thioesterase 8 isoform X3

    Conserved Domains (1) summary
    TIGR00189
    Location:3224
    tesB; acyl-CoA thioesterase II

RNA

  1. XR_001781109.3 RNA Sequence

    Related
    ENSMUST00000134611.4