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ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 170784, updated on 23-Apr-2026
Official Symbol
ube4bprovided by ZNC
Official Full Name
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-020205-1
See related
Ensembl:ENSDARG00000037017 AllianceGenome:ZFIN:ZDB-GENE-020205-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
UFD2; zgc:109766
Summary
Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in ERAD pathway and protein polyubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in female organism; heart; and skeletal muscle. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See ube4b in Genome Data Viewer
Location:
chromosome: 23
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 23 NC_133198.1 (32447507..32493899, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 23 NC_007134.7 (29507315..29553712, complement)

Chromosome 23 - NC_133198.1Genomic Context describing neighboring genes Neighboring gene phosphogluconate dehydrogenase Neighboring gene kinesin family member 1B Neighboring gene nmnat1-rbp7a readthrough Neighboring gene retinol binding protein 7a, cellular Neighboring gene nicotinamide nucleotide adenylyltransferase 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells. Mammen AL, et al. PLoS One, 2011. PMID 22174917, Free PMC Article
  2. The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. Mahoney JA, et al. Biochem J, 2002 Feb 1. PMID 11802788, Free PMC Article
  3. Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Szenker-Ravi E, et al. Nat Genet, 2022 Jan. PMID 34903892
  4. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.
    Title: A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC109766

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ubiquitin conjugation factor E4 B
Names
UBE4B-II splice
NP_919343.2
XP_021325394.1
XP_068072761.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194362.2 → NP_919343.2  ubiquitin conjugation factor E4 B

    Status: VALIDATED

    Source sequence(s)
    EH441473, EH459986, EH552968, JBMGRA010000023
    UniProtKB/TrEMBL
    A0A8M1P8S1, F1Q5A9
    Related
    ENSDARP00000053803.6, ENSDART00000053804.8
    Conserved Domains (2) summary
    pfam04564
    Location:1109 → 1179
    U-box; U-box domain
    pfam10408
    Location:472 → 1092
    Ufd2P_core; Ubiquitin elongating factor core

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133198.1 Reference GRCz12tu Primary Assembly

    Range
    32447507..32493899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216660.1 → XP_068072761.1  ubiquitin conjugation factor E4 B isoform X2

    UniProtKB/TrEMBL
    A0AB32TIN3
    Related
    ENSDARP00000140193.2, ENSDART00000157773.2

  2. XM_021469719.2 → XP_021325394.1  ubiquitin conjugation factor E4 B isoform X1

    UniProtKB/TrEMBL
    A0A8M9PKI9
    Related
    ENSDARP00000105688.3, ENSDART00000126384.3
    Conserved Domains (3) summary
    pfam10408
    Location:638 → 1258
    Ufd2P_core; Ubiquitin elongating factor core
    cd16658
    Location:1271 → 1345
    RING-Ubox_UBE4B; U-box domain, a modified RING finger, found in ubiquitin conjugation factor E4 B (UBE4B) and similar proteins
    cl26464
    Location:239 → 413
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version

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