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Cd209d CD209d antigen [ Mus musculus (house mouse) ]

Gene ID: 170779, updated on 8-Feb-2024

Summary

Official Symbol
Cd209dprovided by MGI
Official Full Name
CD209d antigenprovided by MGI
Primary source
MGI:MGI:2157947
See related
Ensembl:ENSMUSG00000031495 AllianceGenome:MGI:2157947
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SIGNR3; SIGN-R3; mSIGNR3
Summary
Enables identical protein binding activity and mannose binding activity. Acts upstream of or within defense response to bacterium; endocytosis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 6.1), subcutaneous fat pad adult (RPKM 3.3) and 4 other tissues See more
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Genomic context

See Cd209d in Genome Data Viewer
Location:
8 A1.1; 8 1.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3921824..3928548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3871824..3878548, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Wilms' tumour 1-associating protein pseudogene Neighboring gene CD209e antigen Neighboring gene STARR-seq mESC enhancer starr_20599 Neighboring gene STARR-seq mESC enhancer starr_20600 Neighboring gene STARR-seq mESC enhancer starr_20601 Neighboring gene CD209b antigen Neighboring gene CD209c antigen

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CD209 antigen-like protein D
Names
DC-SIGN-related protein 3
DC-SIGNR3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130904.2NP_570974.1  CD209 antigen-like protein D

    See identical proteins and their annotated locations for NP_570974.1

    Status: PROVISIONAL

    Source sequence(s)
    AF373411
    Consensus CDS
    CCDS22075.1
    UniProtKB/Swiss-Prot
    Q8VIK4, Q91ZW8
    UniProtKB/TrEMBL
    Q3UW57
    Related
    ENSMUSP00000011445.7, ENSMUST00000011445.8
    Conserved Domains (1) summary
    cd03590
    Location:106228
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    3921824..3928548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242039.3XP_011240341.1  CD209 antigen-like protein D isoform X1

    Conserved Domains (1) summary
    cl02432
    Location:106186
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain