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Adgrl4 adhesion G protein-coupled receptor L4 [ Mus musculus (house mouse) ]

Gene ID: 170757, updated on 18-Apr-2024

Summary

Official Symbol
Adgrl4provided by MGI
Official Full Name
adhesion G protein-coupled receptor L4provided by MGI
Primary source
MGI:MGI:2655562
See related
Ensembl:ENSMUSG00000039167 AllianceGenome:MGI:2655562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etl; ETL1; Eltd1; 1110033N21Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and protein-containing complex assembly. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in blood vessel. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 19.1), subcutaneous fat pad adult (RPKM 9.6) and 19 other tissues See more
Orthologs
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Genomic context

Location:
3 H3; 3 76.76 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151143519..151250718)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (151437882..151545081)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene microRNA 3963 Neighboring gene RIKEN cDNA 4930555A03 gene Neighboring gene predicted gene, 24458 Neighboring gene STARR-seq mESC enhancer starr_09275 Neighboring gene interferon-induced protein 44

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor L4
Names
EGF, latrophilin seven transmembrane domain containing 1
EGF, latrophilin seven transmembrane domain-containing protein 1
EGF-TM7 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133222.3NP_573485.2  adhesion G protein-coupled receptor L4 precursor

    See identical proteins and their annotated locations for NP_573485.2

    Status: VALIDATED

    Source sequence(s)
    AC127233
    Consensus CDS
    CCDS17910.1
    UniProtKB/Swiss-Prot
    E9QLT4, Q91W44, Q923X1
    Related
    ENSMUSP00000041939.8, ENSMUST00000046977.12
    Conserved Domains (4) summary
    smart00179
    Location:5891
    EGF_CA; Calcium-binding EGF-like domain
    pfam01825
    Location:417461
    GPS; GPCR proteolysis site, GPS, motif
    pfam16489
    Location:190370
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:473709
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    151143519..151250718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)