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Adgrl4 adhesion G protein-coupled receptor L4 [ Mus musculus (house mouse) ]

Gene ID: 170757, updated on 5-Jul-2025
Official Symbol
Adgrl4provided by MGI
Official Full Name
adhesion G protein-coupled receptor L4provided by MGI
Primary source
MGI:MGI:2655562
See related
Ensembl:ENSMUSG00000039167 AllianceGenome:MGI:2655562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etl; ETL1; Eltd1; 1110033N21Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and protein-containing complex assembly. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Is expressed in brain; cardiovascular system; lung; metanephros; and skeletal muscle. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in lung adult (RPKM 19.1), subcutaneous fat pad adult (RPKM 9.6) and 19 other tissues See more
Orthologs
human all
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See Adgrl4 in Genome Data Viewer
Location:
3 H3; 3 76.76 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151143519..151250718)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (151437882..151545081)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene microRNA 3963 Neighboring gene RIKEN cDNA 4930555A03 gene Neighboring gene predicted gene, 24458 Neighboring gene STARR-seq mESC enhancer starr_09275 Neighboring gene interferon-induced protein 44

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma. Huang H, et al. Neuro Oncol, 2022 Mar 12. PMID 34347079, Free PMC Article
  2. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. Xiao J, et al. PLoS One, 2012. PMID 22606234, Free PMC Article
  3. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. Nechiporuk T, et al. J Biol Chem, 2001 Feb 9. PMID 11050079
  4. The EGF-TM7 family: a postgenomic view. Kwakkenbos MJ, et al. Immunogenetics, 2004 Jan. PMID 14647991
  5. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Terskikh AV, et al. Proc Natl Acad Sci U S A, 2001 Jul 3. PMID 11438738, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
    Title: ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
  2. loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.
    Title: Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).
  3. ELTD1 deficiency exacerbates cardiac hypertrophy and cardiac function induced by aortic banding-induced pressure overload by promoting both cardiomyocyte hypertrophy and cardiac fibrosis.
    Title: Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (7)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
adhesion G protein-coupled receptor L4
Names
EGF, latrophilin seven transmembrane domain containing 1
EGF, latrophilin seven transmembrane domain-containing protein 1
EGF-TM7 receptor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133222.3 → NP_573485.2  adhesion G protein-coupled receptor L4 precursor

    See identical proteins and their annotated locations for NP_573485.2

    Status: VALIDATED

    Source sequence(s)
    AC127233
    Consensus CDS
    CCDS17910.1
    UniProtKB/Swiss-Prot
    E9QLT4, Q91W44, Q923X1
    Related
    ENSMUSP00000041939.8, ENSMUST00000046977.12
    Conserved Domains (4) summary
    smart00179
    Location:58 → 91
    EGF_CA; Calcium-binding EGF-like domain
    pfam01825
    Location:417 → 461
    GPS; GPCR proteolysis site, GPS, motif
    pfam16489
    Location:190 → 370
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:473 → 709
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    151143519..151250718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923X1.3 GenPept UniProtKB/Swiss-Prot:Q923X1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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