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Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound [ Mus musculus (house mouse) ]

Gene ID: 170745, updated on 26-Sep-2022

Summary

Official Symbol
Xpnpep2provided by MGI
Official Full Name
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundprovided by MGI
Primary source
MGI:MGI:2180001
See related
Ensembl:ENSMUSG00000037005 AllianceGenome:MGI:2180001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mAPP; 9030008G12Rik
Summary
Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular exosome. Is expressed in brain; forelimb bud; large intestine; and neural retina. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 66.4), small intestine adult (RPKM 32.1) and 3 other tissues See more
Orthologs
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Genomic context

See Xpnpep2 in Genome Data Viewer
Location:
X; X A4
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47195790..47225859)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48106913..48136982)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene calmodulin 2 pseudogene Neighboring gene apelin Neighboring gene SAM and SH3 domain containing 3 Neighboring gene zinc finger, DHHC domain containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
xaa-Pro aminopeptidase 2
Names
X-prolyl aminopeptidase 2
membrane-bound APP
membrane-bound aminopeptidase P
NP_001276658.1
NP_573476.2
XP_006541495.1
XP_036017721.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289729.1NP_001276658.1  xaa-Pro aminopeptidase 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AF428102, AK078835, AK085520, AK164538, AL672274
    Consensus CDS
    CCDS81125.1
    UniProtKB/Swiss-Prot
    B1AVD1
    UniProtKB/TrEMBL
    B1AVD2
    Related
    ENSMUSP00000110652.4, ENSMUST00000115000.4
    Conserved Domains (5) summary
    COG0006
    Location:367656
    PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
    cd01085
    Location:432651
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:53177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16188
    Location:651715
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:202428
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
  2. NM_133213.2NP_573476.2  xaa-Pro aminopeptidase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_573476.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, compared to variant 2. This results in a shorter protein (isoform 1), compared to isoform 2.
    Source sequence(s)
    AF428102, AK164538, AL672274
    Consensus CDS
    CCDS30106.1
    UniProtKB/Swiss-Prot
    B1AVD1, Q91ZH9
    Related
    ENSMUSP00000076951.5, ENSMUST00000077775.11
    Conserved Domains (4) summary
    cd01085
    Location:365584
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:54177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16188
    Location:584648
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:195361
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    47195790..47225859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541432.1XP_006541495.1  xaa-Pro aminopeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006541495.1

    UniProtKB/Swiss-Prot
    B1AVD1, Q91ZH9
    Conserved Domains (4) summary
    cd01085
    Location:365584
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:54177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16188
    Location:584648
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:195361
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
  2. XM_036161828.1XP_036017721.1  xaa-Pro aminopeptidase 2 isoform X2

    UniProtKB/TrEMBL
    Q8BU59
    Related
    ENSMUSP00000110650.2, ENSMUST00000114998.8
    Conserved Domains (3) summary
    cd01085
    Location:365582
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam01321
    Location:54177
    Creatinase_N; Creatinase/Prolidase N-terminal domain
    pfam16189
    Location:195361
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain