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Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 [ Mus musculus (house mouse) ]

Gene ID: 170738, updated on 18-Sep-2024

Summary

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Official Symbol
Kcnh7provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 7provided by MGI
Primary source
MGI:MGI:2159566
See related
Ensembl:ENSMUSG00000059742 AllianceGenome:MGI:2159566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
erg3; Kv11.3; 9330137I11Rik
Summary
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in membrane repolarization during action potential and potassium ion transmembrane transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including future brain; heart; nervous system; retina; and skin. Orthologous to human KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.9), frontal lobe adult (RPKM 1.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnh7 in Genome Data Viewer
Location:
2 C1.3; 2 36.5 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62524428..63014980, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62693410..63184287, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10108 Neighboring gene STARR-positive B cell enhancer ABC_E4458 Neighboring gene STARR-positive B cell enhancer ABC_E1006 Neighboring gene STARR-seq mESC enhancer starr_04644 Neighboring gene STARR-seq mESC enhancer starr_04645 Neighboring gene predicted gene, 39839 Neighboring gene interferon induced with helicase C domain 1 Neighboring gene soc-2 (suppressor of clear) homolog pseudogene Neighboring gene grancalcin Neighboring gene STARR-seq mESC enhancer starr_04646 Neighboring gene predicted gene, 22020 Neighboring gene predicted gene 13569 Neighboring gene STARR-seq mESC enhancer starr_04647 Neighboring gene predicted gene, 54156 Neighboring gene predicted gene, 52513 Neighboring gene STARR-seq mESC enhancer starr_04648 Neighboring gene predicted gene, 34110 Neighboring gene predicted gene, 34291 Neighboring gene STARR-seq mESC enhancer starr_04649 Neighboring gene STARR-seq mESC enhancer starr_04650 Neighboring gene STARR-seq mESC enhancer starr_04651 Neighboring gene predicted gene, 23503

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice. Xiao K, et al. J Physiol, 2018 Oct. PMID 30016551, Free PMC Article
  2. Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT(2) Deficits. Grønli J, et al. Sleep, 2016 Dec 1. PMID 28057087, Free PMC Article
  3. Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons. Hardman RM, et al. J Physiol, 2009 Jun 1. PMID 19359372, Free PMC Article
  4. Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3. Polvani S, et al. Gene Expr Patterns, 2003 Dec. PMID 14643686
  5. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Ding Y, et al. Elife, 2022 Oct 18. PMID 36255053, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low ERG3 expression is associated with epilepsy.
    Title: ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice.
  2. Egr3 has an essential role in regulating cortical arousal, wakefulness, and sleep, presumably by its regulation of 5-HT2 receptors.
    Title: Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT(2) Deficits.
  3. ERG3 K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.
    Title: Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons.
  4. erg3 gene expression pattern in the developing embryo.
    Title: Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily H member 7
Names
ERG-3
eag-related protein 3
ether-a-go-go-related gene potassium channel 3
ether-a-go-go-related protein 3
potassium channel protein erg3
voltage-gated potassium channel subunit Kv11.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133207.2 → NP_573470.2  potassium voltage-gated channel subfamily H member 7

    See identical proteins and their annotated locations for NP_573470.2

    Status: VALIDATED

    Source sequence(s)
    AL928663, AL928689, AL929246
    Consensus CDS
    CCDS38128.1
    UniProtKB/Swiss-Prot
    A2AUY8, Q9ER47
    Related
    ENSMUSP00000074563.4, ENSMUST00000075052.10
    Conserved Domains (6) summary
    COG0664
    Location:739 → 869
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:745 → 856
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 130
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:448 → 671
    Ion_trans; Ion transport protein
    pfam07885
    Location:614 → 668
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    62524428..63014980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239315.4 → XP_011237617.1  potassium voltage-gated channel subfamily H member 7 isoform X5

    Conserved Domains (3) summary
    cd00038
    Location:739 → 850
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:402 → 664
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  2. XM_036158885.1 → XP_036014778.1  potassium voltage-gated channel subfamily H member 7 isoform X4

    Conserved Domains (3) summary
    cd00038
    Location:743 → 854
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:410 → 672
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  3. XM_011239314.4 → XP_011237616.1  potassium voltage-gated channel subfamily H member 7 isoform X3

    Conserved Domains (3) summary
    cd00038
    Location:747 → 858
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:410 → 672
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  4. XM_017315931.3 → XP_017171420.1  potassium voltage-gated channel subfamily H member 7 isoform X6

    Conserved Domains (3) summary
    cd00038
    Location:612 → 723
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:388 → 537
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  5. XM_006498825.4 → XP_006498888.1  potassium voltage-gated channel subfamily H member 7 isoform X2

    Conserved Domains (3) summary
    cd00038
    Location:750 → 861
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:417 → 679
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  6. XM_011239313.4 → XP_011237615.1  potassium voltage-gated channel subfamily H member 7 isoform X1

    Conserved Domains (3) summary
    cd00038
    Location:753 → 864
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:417 → 679
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  7. XM_011239317.4 → XP_011237619.1  potassium voltage-gated channel subfamily H member 7 isoform X13

    Conserved Domains (2) summary
    cd00038
    Location:241 → 352
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:7 → 166
    Ion_trans; Ion transport protein

  8. XM_036158888.1 → XP_036014781.1  potassium voltage-gated channel subfamily H member 7 isoform X8

    Conserved Domains (1) summary
    PLN03192
    Location:47 → 520
    PLN03192; Voltage-dependent potassium channel; Provisional

  9. XM_017315932.2 → XP_017171421.1  potassium voltage-gated channel subfamily H member 7 isoform X7

    Conserved Domains (3) summary
    cd00038
    Location:754 → 865
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:417 → 679
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  10. XM_006498828.2 → XP_006498891.1  potassium voltage-gated channel subfamily H member 7 isoform X11

    Conserved Domains (2) summary
    pfam00520
    Location:402 → 664
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  11. XM_017315936.3 → XP_017171425.1  potassium voltage-gated channel subfamily H member 7 isoform X12

    Conserved Domains (2) summary
    pfam00520
    Location:409 → 671
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  12. XM_030247906.2 → XP_030103766.1  potassium voltage-gated channel subfamily H member 7 isoform X14

    UniProtKB/TrEMBL
    Q8CC38
    Related
    ENSMUSP00000108073.2, ENSMUST00000112454.8
    Conserved Domains (2) summary
    pfam00520
    Location:417 → 579
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  13. XM_006498826.2 → XP_006498889.1  potassium voltage-gated channel subfamily H member 7 isoform X9

    Conserved Domains (2) summary
    pfam00520
    Location:417 → 679
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

  14. XM_006498827.2 → XP_006498890.1  potassium voltage-gated channel subfamily H member 7 isoform X10

    Conserved Domains (2) summary
    pfam00520
    Location:417 → 679
    Ion_trans; Ion transport protein
    pfam13426
    Location:29 → 134
    PAS_9; PAS domain

RNA

  1. XR_374421.2 RNA Sequence

  2. XR_001781102.2 RNA Sequence

  3. XR_374422.4 RNA Sequence

  4. XR_374420.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER47.2 GenPept UniProtKB/Swiss-Prot:Q9ER47

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