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Znrf1 zinc and ring finger 1 [ Mus musculus (house mouse) ]

Gene ID: 170737, updated on 5-Jan-2023

Summary

Official Symbol
Znrf1provided by MGI
Official Full Name
zinc and ring finger 1provided by MGI
Primary source
MGI:MGI:2177308
See related
Ensembl:ENSMUSG00000033545 AllianceGenome:MGI:2177308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf42; Zrfp1; nin283; B830022L21Rik
Summary
Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol; endosome; and membrane. Is expressed in central nervous system; genitourinary system; and retina nuclear layer. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 159.2), whole brain E14.5 (RPKM 40.2) and 20 other tissues See more
Orthologs
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Genomic context

See Znrf1 in Genome Data Viewer
Location:
8; 8 E1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112262652..112352352)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111536484..111625720)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24793 Neighboring gene WD repeat domain 59 Neighboring gene lactate dehydrogenase D Neighboring gene zinc finger protein 1 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC101991

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZNRF1
Names
RING-type E3 ubiquitin transferase ZNRF1
nerve injury-induced gene 283 protein
peripheral nerve injury protein nin283
ring finger protein 42
zinc ring finger protein 1
zinc/RING finger protein 1
NP_001162092.1
NP_001162093.1
NP_001162094.1
NP_001350417.1
NP_001350418.1
NP_573469.1
XP_036009665.1
XP_036009666.1
XP_036009667.1
XP_036009668.1
XP_036009669.1
XP_036009670.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168621.3NP_001162092.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

    See identical proteins and their annotated locations for NP_001162092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS22676.1
    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    UniProtKB/TrEMBL
    A0A6P7R6B3, A0A8C6HKG1
    Related
    ENSMUSP00000126684.2, ENSMUST00000168428.8
    Conserved Domains (1) summary
    cd16694
    Location:182227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  2. NM_001168622.3NP_001162093.1  E3 ubiquitin-protein ligase ZNRF1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS52673.1
    UniProtKB/Swiss-Prot
    Q91V17
    UniProtKB/TrEMBL
    A0A8C6HMY3, E9PZB7
    Related
    ENSMUSP00000127956.2, ENSMUST00000171182.8
    Conserved Domains (1) summary
    cd16694
    Location:150195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  3. NM_001168623.2NP_001162094.1  E3 ubiquitin-protein ligase ZNRF1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 6 both encode the same isoform (c).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS52674.1
    UniProtKB/Swiss-Prot
    Q91V17
    UniProtKB/TrEMBL
    E9PWL2
    Related
    ENSMUSP00000132939.2, ENSMUST00000166859.8
    Conserved Domains (1) summary
    cd16694
    Location:82127
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  4. NM_001363488.2NP_001350417.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS22676.1
    UniProtKB/Swiss-Prot
    Q8C5D7
    UniProtKB/TrEMBL
    A0A6P7R6B3, A0A8C6HKG1
    Related
    ENSMUSP00000133993.2, ENSMUST00000173506.8
    Conserved Domains (1) summary
    cd16694
    Location:182227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  5. NM_001363489.1NP_001350418.1  E3 ubiquitin-protein ligase ZNRF1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 4, encodes isoform c.
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS52674.1
    UniProtKB/TrEMBL
    E9PWL2
    Related
    ENSMUSP00000134634.2, ENSMUST00000174333.8
    Conserved Domains (1) summary
    cd16694
    Location:82127
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  6. NM_133206.5NP_573469.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

    See identical proteins and their annotated locations for NP_573469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122364, AC127356
    Consensus CDS
    CCDS22676.1
    UniProtKB/Swiss-Prot
    Q8C5D7, Q91V17
    UniProtKB/TrEMBL
    A0A6P7R6B3, A0A8C6HKG1
    Related
    ENSMUSP00000092799.6, ENSMUST00000095176.12
    Conserved Domains (1) summary
    cd16694
    Location:182227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

RNA

  1. NR_156703.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC122364, AC127356
  2. NR_156704.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC122364, AC127356

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112262652..112352352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153772.1XP_036009665.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5D7
    UniProtKB/TrEMBL
    A0A6P7R6B3, A0A8C6HKG1
    Conserved Domains (1) summary
    cd16694
    Location:182227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  2. XM_036153773.1XP_036009666.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5D7
    UniProtKB/TrEMBL
    A0A6P7R6B3, A0A8C6HKG1
    Conserved Domains (1) summary
    cd16694
    Location:182227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  3. XM_036153774.1XP_036009667.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5D7
    UniProtKB/TrEMBL
    A0A6P7R6B3, A0A8C6HKG1
    Related
    ENSMUSP00000133309.2, ENSMUST00000172856.8
    Conserved Domains (1) summary
    cd16694
    Location:182227
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  4. XM_036153775.1XP_036009668.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    A0A8C6HMY3, E9PZB7
    Conserved Domains (1) summary
    cd16694
    Location:150195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  5. XM_036153776.1XP_036009669.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    A0A8C6HMY3, E9PZB7
    Conserved Domains (1) summary
    cd16694
    Location:150195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
  6. XM_036153777.1XP_036009670.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

    UniProtKB/TrEMBL
    A0A8C6HMY3, E9PZB7
    Conserved Domains (1) summary
    cd16694
    Location:150195
    mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins