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Arr3 arrestin 3, retinal [ Mus musculus (house mouse) ]

Gene ID: 170735, updated on 25-Oct-2022

Summary

Official Symbol
Arr3provided by MGI
Official Full Name
arrestin 3, retinalprovided by MGI
Primary source
MGI:MGI:2159617
See related
Ensembl:ENSMUSG00000060890 AllianceGenome:MGI:2159617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Car; Arr4; Carr; Carfl
Summary
Enables opsin binding activity and phosphoprotein binding activity. Acts upstream of or within endocytosis and regulation of protein phosphorylation. Located in photoreceptor outer segment and synapse. Is expressed in retina. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ARR3 (arrestin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Arr3 in Genome Data Viewer
Location:
X; X C3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99649086..99662099)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100605480..100618493)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 4 Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4 Neighboring gene predicted gene, 52438

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables opsin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arrestin-C
Names
X-arrestin
arrestin 4
retinal cone arrestin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133205.3NP_573468.1  arrestin-C

    See identical proteins and their annotated locations for NP_573468.1

    Status: VALIDATED

    Source sequence(s)
    AL671299, BX276129
    Consensus CDS
    CCDS41075.1
    UniProtKB/Swiss-Prot
    Q9EQP6
    Related
    ENSMUSP00000109398.2, ENSMUST00000113769.8
    Conserved Domains (2) summary
    smart01017
    Location:190353
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:14171
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    99649086..99662099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527865.3XP_006527928.1  arrestin-C isoform X5

    Conserved Domains (2) summary
    smart01017
    Location:236437
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. XM_006527869.3XP_006527932.1  arrestin-C isoform X10

    Conserved Domains (2) summary
    smart01017
    Location:236429
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. XM_006527872.3XP_006527935.1  arrestin-C isoform X14

    Conserved Domains (2) summary
    smart01017
    Location:236401
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_006527862.3XP_006527925.1  arrestin-C isoform X1

    Conserved Domains (2) summary
    smart01017
    Location:236437
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  5. XM_006527867.3XP_006527930.1  arrestin-C isoform X8

    Conserved Domains (2) summary
    smart01017
    Location:236437
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  6. XM_006527863.3XP_006527926.1  arrestin-C isoform X3

    Conserved Domains (2) summary
    smart01017
    Location:236429
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  7. XM_006527871.3XP_006527934.1  arrestin-C isoform X13

    Conserved Domains (2) summary
    smart01017
    Location:236429
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  8. XM_006527864.3XP_006527927.1  arrestin-C isoform X4

    Conserved Domains (2) summary
    smart01017
    Location:236409
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  9. XM_006527868.3XP_006527931.1  arrestin-C isoform X9

    Conserved Domains (2) summary
    smart01017
    Location:236401
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  10. XM_006527870.3XP_006527933.1  arrestin-C isoform X11

    Conserved Domains (2) summary
    smart01017
    Location:236399
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59217
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  11. XM_017318398.2XP_017173887.1  arrestin-C isoform X2

    Conserved Domains (2) summary
    smart01017
    Location:235436
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59216
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  12. XM_017318400.2XP_017173889.1  arrestin-C isoform X12

    Conserved Domains (2) summary
    smart01017
    Location:235398
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:59216
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  13. XM_006527873.3XP_006527936.1  arrestin-C isoform X16

    Conserved Domains (2) summary
    smart01017
    Location:236361
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:5997
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  14. XM_006527866.3XP_006527929.1  arrestin-C isoform X6

    Conserved Domains (2) summary
    smart01017
    Location:206407
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:29187
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  15. XM_017318399.2XP_017173888.1  arrestin-C isoform X7

    Conserved Domains (2) summary
    smart01017
    Location:205406
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:29186
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  16. XM_017318401.2XP_017173890.1  arrestin-C isoform X15

    Conserved Domains (2) summary
    smart01017
    Location:205368
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:29186
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  17. XM_017318402.2XP_017173891.1  arrestin-C isoform X17

    Conserved Domains (2) summary
    smart01017
    Location:75276
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:456
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  18. XM_017318404.2XP_017173893.1  arrestin-C isoform X17

    Conserved Domains (2) summary
    smart01017
    Location:75276
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:456
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  19. XM_017318403.2XP_017173892.1  arrestin-C isoform X17

    Conserved Domains (2) summary
    smart01017
    Location:75276
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:456
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  20. XM_006527875.4XP_006527938.1  arrestin-C isoform X17

    Conserved Domains (2) summary
    smart01017
    Location:75276
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:456
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. XR_386916.3 RNA Sequence

  2. XR_003953000.1 RNA Sequence

  3. XR_004940328.1 RNA Sequence