Anp32b acidic nuclear phosphoprotein 32 family member B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anp32bprovided by RGD
Official Full Name: acidic nuclear phosphoprotein 32 family member Bprovided by RGD
Primary source: RGD:621285
See related: Ensembl:ENSRNOG00000009266 AllianceGenome:RGD:621285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PAL31
Summary: Predicted to enable RNA polymerase binding activity and histone binding activity. Involved in negative regulation of apoptotic process; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Predicted to colocalize with nucleolus. Orthologous to human ANP32B (acidic nuclear phosphoprotein 32 family member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 139.2), Thymus (RPKM 116.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (60743077..60765726)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (62070709..62094633)

Chromosome 5 - NC_051340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that PAL31upregulation might be beneficial after spinal cord injury. Reactive gliosis might become a good target for future therapeutic interventions.
Title: Cytoprotective and anti-inflammatory effects of PAL31 overexpression in glial cells.
PAL31 may be involved in the modulation of the inflammatory response and, at the same time, prevent apoptosis process of macrophage after spinal cord injury
Title: PAL31 may play an important role as inflammatory modulator in the repair process of the spinal cord injury rat.
PAL31 can suppress caspase-3 activity but not cytochrome c release in vitro, indicating that PAL31 is a direct caspase-3 inhibitor.
Title: Proliferation related acidic leucine-rich protein PAL31 functions as a caspase-3 inhibitor.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables histone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member B

Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; proliferation-related acidic leucine-rich protein PAL31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131911.2 → NP_571986.1 acidic leucine-rich nuclear phosphoprotein 32 family member B

See identical proteins and their annotated locations for NP_571986.1

Status: PROVISIONAL

Source sequence(s)

BC086508

UniProtKB/Swiss-Prot

Q9EST6

Related

ENSRNOP00000012478.5, ENSRNOT00000012478.6

Conserved Domains (4) summary

COG4886
Location:16 → 115

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:19 → 43

LRR_RI; leucine-rich repeat [structural motif]

sd00035
Location:90 → 113

LRR_NTF; leucine-rich repeat [structural motif]

pfam14580
Location:71 → 146

LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

NC_051340.1 Reference mRatBN7.2 Primary Assembly

Range

60743077..60765726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109198.1 → XP_038965126.1 acidic leucine-rich nuclear phosphoprotein 32 family member B isoform X1

Conserved Domains (4) summary

COG4886
Location:16 → 115

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:19 → 43

LRR_RI; leucine-rich repeat [structural motif]

sd00035
Location:90 → 113

LRR_NTF; leucine-rich repeat [structural motif]

pfam14580
Location:71 → 146

LRR_9; Leucine-rich repeat
XM_039109199.1 → XP_038965127.1 acidic leucine-rich nuclear phosphoprotein 32 family member B isoform X2

Conserved Domains (4) summary

COG4886
Location:16 → 115

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:19 → 43

LRR_RI; leucine-rich repeat [structural motif]

sd00035
Location:90 → 113

LRR_NTF; leucine-rich repeat [structural motif]

pfam14580
Location:71 → 146

LRR_9; Leucine-rich repeat