U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nxf7 nuclear RNA export factor 7 [ Mus musculus (house mouse) ]

Gene ID: 170722, updated on 26-Sep-2022

Summary

Official Symbol
Nxf7provided by MGI
Official Full Name
nuclear RNA export factor 7provided by MGI
Primary source
MGI:MGI:2159343
See related
Ensembl:ENSMUSG00000031410 AllianceGenome:MGI:2159343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nx7; Nxf6; nxf-a; nfx-a1; nxf-a2
Summary
Enables mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in cytoplasm. Is expressed in brain; central nervous system ganglion; extraembryonic component; retina; and testis. Orthologous to human NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 40.5) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nxf7 in Genome Data Viewer
Location:
X F1; X 57.25 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134480304..134499530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135579555..135598781, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22233 Neighboring gene preferentially expressed antigen in melanoma-like 3 pseudogene Neighboring gene PRAME like, X-linked 1 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene t-complex 11 family, X-linked 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear RNA export factor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear RNA export factor 7
Names
nuclear RNA export factor 6
nuclear export factor a

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379677.1NP_001366606.1  nuclear RNA export factor 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671911
    Conserved Domains (6) summary
    smart00804
    Location:548609
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:217259
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:110191
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:258320
    LRR_8; Leucine rich repeat
    cd21340
    Location:224364
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl09109
    Location:383529
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
  2. NM_130888.2NP_570958.1  nuclear RNA export factor 7 isoform 1

    See identical proteins and their annotated locations for NP_570958.1

    Status: VALIDATED

    Source sequence(s)
    AL671911
    Consensus CDS
    CCDS30406.1
    UniProtKB/TrEMBL
    Q80SZ6
    Related
    ENSMUSP00000108788.2, ENSMUST00000113163.8
    Conserved Domains (5) summary
    smart00804
    Location:558619
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:227269
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam13855
    Location:269330
    LRR_8; Leucine rich repeat
    pfam09162
    Location:119201
    Tap-RNA_bind; Tap, RNA-binding
    cl09109
    Location:393539
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    134480304..134499530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528509.3XP_006528572.1  nuclear RNA export factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006528572.1

    UniProtKB/TrEMBL
    Q80SZ6
    Conserved Domains (5) summary
    smart00804
    Location:558619
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:227269
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam13855
    Location:269330
    LRR_8; Leucine rich repeat
    pfam09162
    Location:119201
    Tap-RNA_bind; Tap, RNA-binding
    cl09109
    Location:393539
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
  2. XM_006528511.4XP_006528574.1  nuclear RNA export factor 7 isoform X2

    See identical proteins and their annotated locations for XP_006528574.1

    Conserved Domains (6) summary
    smart00804
    Location:548609
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:217259
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:110191
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:258320
    LRR_8; Leucine rich repeat
    cd21340
    Location:224364
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl09109
    Location:383529
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...