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Card14 caspase recruitment domain family, member 14 [ Mus musculus (house mouse) ]

Gene ID: 170720, updated on 12-May-2024

Summary

Official Symbol
Card14provided by MGI
Official Full Name
caspase recruitment domain family, member 14provided by MGI
Primary source
MGI:MGI:2386258
See related
Ensembl:ENSMUSG00000013483 AllianceGenome:MGI:2386258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bimp2; CARMA2
Summary
Predicted to enable CARD domain binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of protein phosphorylation; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within apoptotic process. Predicted to be located in aggresome and cytosol. Predicted to be active in cytoplasm. Is expressed in gut; nose; and vibrissa. Used to study psoriasis 2. Human ortholog(s) of this gene implicated in pityriasis rubra pilaris and psoriasis 2. Orthologous to human CARD14 (caspase recruitment domain family member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 7.9), large intestine adult (RPKM 5.4) and 19 other tissues See more
Orthologs
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Genomic context

See Card14 in Genome Data Viewer
Location:
11 E2; 11 83.36 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119197923..119236205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119307093..119345379)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glucosidase, alpha, acid Neighboring gene STARR-positive B cell enhancer ABC_E7111 Neighboring gene predicted gene, 39483 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene solute carrier family 26, member 11 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene STARR-seq mESC enhancer starr_31317 Neighboring gene microRNA 1932 Neighboring gene ring finger protein 213

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CARD domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables CARD domain binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
caspase recruitment domain-containing protein 14
Names
bcl10-interacting MAGUK protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130886.4NP_570956.1  caspase recruitment domain-containing protein 14

    See identical proteins and their annotated locations for NP_570956.1

    Status: VALIDATED

    Source sequence(s)
    AL645911
    Consensus CDS
    CCDS25715.1
    UniProtKB/Swiss-Prot
    Q99KF0
    Related
    ENSMUSP00000101857.2, ENSMUST00000106250.8
    Conserved Domains (8) summary
    cd00992
    Location:580652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00261
    Location:120364
    Tropomyosin; Tropomyosin
    pfam15898
    Location:205275
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd16269
    Location:374385
    GBP_C; coiled coil [structural motif]
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:677738
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:854978
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    cl20817
    Location:282407
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119197923..119236205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532369.4XP_006532432.1  caspase recruitment domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006532432.1

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8841008
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. XM_006532379.5XP_006532442.1  caspase recruitment domain-containing protein 14 isoform X6

    Conserved Domains (4) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
  3. XM_006532378.5XP_006532441.1  caspase recruitment domain-containing protein 14 isoform X5

    Conserved Domains (4) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
  4. XM_006532371.5XP_006532434.1  caspase recruitment domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006532434.1

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8841008
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. XM_006532366.4XP_006532429.1  caspase recruitment domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006532429.1

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8841008
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  6. XM_006532373.3XP_006532436.1  caspase recruitment domain-containing protein 14 isoform X2

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:580652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:677738
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8771001
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  7. XM_006532374.4XP_006532437.1  caspase recruitment domain-containing protein 14 isoform X3

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:579651
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:676737
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8761000
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  8. XM_006532370.5XP_006532433.1  caspase recruitment domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006532433.1

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8841008
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  9. XM_006532372.5XP_006532435.1  caspase recruitment domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006532435.1

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8841008
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  10. XM_006532367.5XP_006532430.1  caspase recruitment domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006532430.1

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8841008
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  11. XM_006532375.3XP_006532438.1  caspase recruitment domain-containing protein 14 isoform X4

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:861985
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  12. XM_006532368.5XP_006532431.1  caspase recruitment domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006532431.1

    Conserved Domains (5) summary
    COG1196
    Location:132410
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:587659
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14633
    Location:19104
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl17036
    Location:684745
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8841008
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...