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ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16 [ Homo sapiens (human) ]

Gene ID: 170690, updated on 11-Jun-2021

Summary

Official Symbol
ADAMTS16provided by HGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 16provided by HGNC
Primary source
HGNC:HGNC:17108
See related
Ensembl:ENSG00000145536 MIM:607510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADAMTS16s
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]
Expression
Biased expression in ovary (RPKM 5.4), gall bladder (RPKM 4.3) and 8 other tissues See more
Orthologs
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Genomic context

See ADAMTS16 in Genome Data Viewer
Location:
5p15.32
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (5140330..5320304)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (5140443..5320417)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAMTS16 divergent transcript Neighboring gene RN7SK pseudogene 73 Neighboring gene uncharacterized LOC101929200 Neighboring gene ALG3 pseudogene 1 Neighboring gene MT-CO1 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan for breast cancer risk haplotypes among African American women.
GeneReviews: Not available
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in male gamete generation IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 16
Names
ADAM-TS 16
ADAM-TS16
ADAMTS-16
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139056.4NP_620687.2  A disintegrin and metalloproteinase with thrombospondin motifs 16 preproprotein

    See identical proteins and their annotated locations for NP_620687.2

    Status: REVIEWED

    Source sequence(s)
    AB095949, AC091978, BQ774377, DQ266047
    Consensus CDS
    CCDS43299.1
    UniProtKB/Swiss-Prot
    Q8TE57
    UniProtKB/TrEMBL
    Q2XQZ0
    Related
    ENSP00000274181.7, ENST00000274181.7
    Conserved Domains (6) summary
    smart00209
    Location:589641
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:290491
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:292495
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:83204
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:746858
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:11901220
    PLAC; PLAC (protease and lacunin) domain

RNA

  1. NR_136935.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC091978, BQ774377, DQ266047

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    5140330..5320304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001742032.1 RNA Sequence

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