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Ly6e lymphocyte antigen 6 family member E [ Mus musculus (house mouse) ]

Gene ID: 17069, updated on 9-May-2024

Summary

Official Symbol
Ly6eprovided by MGI
Official Full Name
lymphocyte antigen 6 family member Eprovided by MGI
Primary source
MGI:MGI:106651
See related
Ensembl:ENSMUSG00000022587 AllianceGenome:MGI:106651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly67; Tsa1; RIG-E; Sca-2; TSA-1
Summary
Enables acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Involved in negative regulation of viral entry into host cell. Acts upstream of or within several processes, including epinephrine secretion; norepinephrine metabolic process; and ventricular cardiac muscle tissue morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be anchored component of membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; immune system; and skeletal musculature. Orthologous to human LY6E (lymphocyte antigen 6 family member E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 431.0), spleen adult (RPKM 360.8) and 23 other tissues See more
Orthologs
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Genomic context

See Ly6e in Genome Data Viewer
Location:
15 D3; 15 34.29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74826874..74831753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74955025..74959904)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6610 Neighboring gene STARR-positive B cell enhancer ABC_E1173 Neighboring gene predicted gene, 39556 Neighboring gene STARR-seq mESC enhancer starr_39002 Neighboring gene STARR-positive B cell enhancer ABC_E7383 Neighboring gene predicted gene 28068 Neighboring gene lymphocyte antigen 6 family member I Neighboring gene predicted gene 8000

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine receptor inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lymphocyte antigen 6E
Names
lymphocyte antigen 6 complex, locus E
stem cell antigen 2
thymic shared antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164036.2NP_001157508.2  lymphocyte antigen 6E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 to 7 all encode the same protein.
    Source sequence(s)
    AC124637
    Consensus CDS
    CCDS27538.1
    UniProtKB/TrEMBL
    A0A087WNT2, A0A087WPY4
    Related
    ENSMUSP00000139482.3, ENSMUST00000190810.8
    Conserved Domains (1) summary
    smart00134
    Location:21105
    LU; Ly-6 antigen / uPA receptor -like domain
  2. NM_001164037.2NP_001157509.2  lymphocyte antigen 6E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 to 7 all encode the same protein.
    Source sequence(s)
    AC124637
    Consensus CDS
    CCDS27538.1
    UniProtKB/TrEMBL
    A0A087WNT2, A0A087WPY4
    Related
    ENSMUSP00000141145.3, ENSMUST00000185861.8
    Conserved Domains (1) summary
    smart00134
    Location:21105
    LU; Ly-6 antigen / uPA receptor -like domain
  3. NM_001164038.2NP_001157510.2  lymphocyte antigen 6E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 to 7 all encode the same protein.
    Source sequence(s)
    AC124637, U04268
    Consensus CDS
    CCDS27538.1
    UniProtKB/TrEMBL
    A0A087WNT2, A0A087WPY4
    Related
    ENSMUSP00000140145.3, ENSMUST00000188866.7
    Conserved Domains (1) summary
    smart00134
    Location:21105
    LU; Ly-6 antigen / uPA receptor -like domain
  4. NM_001164039.2NP_001157511.2  lymphocyte antigen 6E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1 to 7 all encode the same protein.
    Source sequence(s)
    AC124637
    Consensus CDS
    CCDS27538.1
    UniProtKB/TrEMBL
    A0A087WNT2, A0A087WPY4
    Conserved Domains (1) summary
    smart00134
    Location:21105
    LU; Ly-6 antigen / uPA receptor -like domain
  5. NM_001164040.2NP_001157512.2  lymphocyte antigen 6E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1 to 7 all encode the same protein.
    Source sequence(s)
    AC124637
    Consensus CDS
    CCDS27538.1
    UniProtKB/TrEMBL
    A0A087WNT2, A0A087WPY4
    Related
    ENSMUSP00000139471.3, ENSMUST00000187606.8
    Conserved Domains (1) summary
    smart00134
    Location:21105
    LU; Ly-6 antigen / uPA receptor -like domain
  6. NM_001374138.1NP_001361067.1  lymphocyte antigen 6E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1 to 7 all encode the same protein.
    Source sequence(s)
    AC124637
    UniProtKB/TrEMBL
    A0A087WNT2, A0A087WPY4
    Related
    ENSMUSP00000140553.3, ENSMUST00000187284.8
    Conserved Domains (1) summary
    smart00134
    Location:21105
    LU; Ly-6 antigen / uPA receptor -like domain
  7. NM_008529.4NP_032555.2  lymphocyte antigen 6E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 to 7 all encode the same protein.
    Source sequence(s)
    AC124637
    Consensus CDS
    CCDS27538.1
    UniProtKB/TrEMBL
    A0A087WNT2, A0A087WPY4
    Related
    ENSMUSP00000139549.3, ENSMUST00000191436.8
    Conserved Domains (1) summary
    smart00134
    Location:21105
    LU; Ly-6 antigen / uPA receptor -like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    74826874..74831753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159201.1XP_036015094.1  lymphocyte antigen 6E isoform X1

    UniProtKB/Swiss-Prot
    Q61128, Q64253, Q99JA5
    Related
    ENSMUSP00000141059.3, ENSMUST00000188042.3
    Conserved Domains (1) summary
    smart00134
    Location:27111
    LU; Ly-6 antigen / uPA receptor -like domain