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ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 [ Homo sapiens (human) ]

Gene ID: 170689, updated on 9-Feb-2020

Summary

Official Symbol
ADAMTS15provided by HGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 15provided by HGNC
Primary source
HGNC:HGNC:16305
See related
Ensembl:ENSG00000166106 MIM:607509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
Expression
Biased expression in fat (RPKM 10.9), placenta (RPKM 8.5) and 13 other tissues See more
Orthologs

Genomic context

See ADAMTS15 in Genome Data Viewer
Location:
11q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (130448876..130478215)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (130318869..130346539)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ZBTB44 divergent transcript Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 8 Neighboring gene uncharacterized LOC105369574 Neighboring gene 11q24.3 proximal HERV-mediated recombination region Neighboring gene BCL2 antagonist/killer 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 15
Names
ADAM-TS 15
ADAM-TS15
ADAMTS-15
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein
metalloprotease disintegrin 15 with thrombospondin domains

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139055.3NP_620686.1  A disintegrin and metalloproteinase with thrombospondin motifs 15 preproprotein

    See identical proteins and their annotated locations for NP_620686.1

    Status: REVIEWED

    Source sequence(s)
    AK130067, AP003459, BC109114, W70305
    Consensus CDS
    CCDS8488.1
    UniProtKB/Swiss-Prot
    Q8TE58
    Related
    ENSP00000299164.2, ENST00000299164.3
    Conserved Domains (5) summary
    smart00209
    Location:519571
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:218424
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:24142
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:683801
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:437506
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    130448876..130478215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271419.4XP_005271476.1  A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

    Conserved Domains (4) summary
    smart00209
    Location:188240
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:352470
    ADAM_spacer1; ADAM-TS Spacer 1
    cl00064
    Location:193
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    cl15456
    Location:106175
    ADAM_CR; ADAM cysteine-rich

RNA

  1. XR_001747783.1 RNA Sequence

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