U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Peg10 paternally expressed 10 [ Mus musculus (house mouse) ]

Gene ID: 170676, updated on 5-Mar-2024

Summary

Official Symbol
Peg10provided by MGI
Official Full Name
paternally expressed 10provided by MGI
Primary source
MGI:MGI:2157785
See related
Ensembl:ENSMUSG00000092035 AllianceGenome:MGI:2157785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edr; HB-1; Mar2; Rtl2; MEF3L; Mart2; MyEF-3; MmPEG10
Summary
This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation, apoptosis and cancer development. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. [provided by RefSeq, Oct 2014]
Expression
Biased expression in placenta adult (RPKM 384.9), adrenal adult (RPKM 56.4) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
6 A1; 6 1.81 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (4747306..4760517)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (4747306..4760517)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38761 Neighboring gene STARR-seq mESC enhancer starr_15017 Neighboring gene STARR-seq mESC enhancer starr_15018 Neighboring gene sarcoglycan, epsilon Neighboring gene STARR-seq mESC enhancer starr_15019 Neighboring gene predicted gene, 51408 Neighboring gene predicted gene 20714

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retrotransposon-derived protein PEG10
Names
MEF3-like protein 1
MyEF-3 like
embryonal carcinoma differentiation regulated protein
mammalian retrotransposon-derived protein 2
myelin expression factor 3
myelin expression factor 3-like protein 1
paternally expressed gene 10 protein
retrotransposon gag domain-containing protein 3
retrotransposon-derived gag-like polyprotein
ty3/Gypsy-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040611.1NP_001035701.1  retrotransposon-derived protein PEG10 isoform 2

    See identical proteins and their annotated locations for NP_001035701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This isoform (2) produced from RF1 in the absence of -1 translational frameshifting has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AB091827, AC084315, BC094558, CF735227, CJ127881
    Consensus CDS
    CCDS57407.1
    UniProtKB/Swiss-Prot
    Q7TN75
    Related
    ENSMUSP00000134963.2, ENSMUST00000176204.8
    Conserved Domains (1) summary
    pfam03732
    Location:174267
    Retrotrans_gag; Retrotransposon gag protein
  2. NM_130877.2NP_570947.2  retrotransposon-derived protein PEG10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has two overlapping open reading frames (RFI and RF2). This longer isoform (1) is derived from RF1/RF2 by -1 translational frameshifting.
    Source sequence(s)
    AB091827, AC084315, BC094558, CF735227, CJ127881
    UniProtKB/TrEMBL
    E9Q3F7
    Conserved Domains (2) summary
    cd00303
    Location:416500
    retropepsin_like; Retropepsins; pepsin-like aspartate proteases
    pfam03732
    Location:174267
    Retrotrans_gag; Retrotransposon gag protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    4747306..4760517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)