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Kirrel kirre like nephrin family adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 170643, updated on 31-Jan-2019

Summary

Official Symbol
Kirrelprovided by MGI
Official Full Name
kirre like nephrin family adhesion molecule 1provided by MGI
Primary source
MGI:MGI:1891396
See related
Ensembl:ENSMUSG00000041734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Neph1; Kirrel1; 6720469N11Rik
Expression
Broad expression in limb E14.5 (RPKM 16.4), subcutaneous fat pad adult (RPKM 10.9) and 21 other tissues See more
Orthologs

Genomic context

See Kirrel in Genome Data Viewer
Location:
3; 3 F1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (87078592..87174747, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (86882514..86978669, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 pseudogene Neighboring gene C-terminal binding protein 2 pseudogene Neighboring gene predicted gene 10705 Neighboring gene Fc receptor-like S, scavenger receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
myosin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of actin filament polymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cell projection membrane ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kin of IRRE-like protein 1
Names
kin of IRRE like 1
kin of irregular chiasm-like protein 1
nephrin 1
nephrin-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170985.1NP_001164456.1  kin of IRRE-like protein 1 precursor

    See identical proteins and their annotated locations for NP_001164456.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC102115, AK032898, AK034569, AY243095, BY736743, CJ106213, CJ128949, CV559096
    Consensus CDS
    CCDS17450.1
    UniProtKB/Swiss-Prot
    Q80W68
    Related
    ENSMUSP00000103243.2, ENSMUST00000107618.8
    Conserved Domains (6) summary
    cd05759
    Location:170251
    Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
    cd05898
    Location:423520
    Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
    smart00410
    Location:346421
    IG_like; Immunoglobulin like
    pfam07679
    Location:54148
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:340421
    Ig_2; Immunoglobulin domain
    cl11960
    Location:57148
    Ig; Immunoglobulin domain
  2. NM_130867.3NP_570937.2  kin of IRRE-like protein 1 precursor

    See identical proteins and their annotated locations for NP_570937.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC102115, AK032898, AK034569, AY243095, CJ106213, CJ128949, CV559096
    Consensus CDS
    CCDS17450.1
    UniProtKB/Swiss-Prot
    Q80W68
    Related
    ENSMUSP00000125525.1, ENSMUST00000159976.7
    Conserved Domains (6) summary
    cd05759
    Location:170251
    Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
    cd05898
    Location:423520
    Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
    smart00410
    Location:346421
    IG_like; Immunoglobulin like
    pfam07679
    Location:54148
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:340421
    Ig_2; Immunoglobulin domain
    cl11960
    Location:57148
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    87078592..87174747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240029.1XP_011238331.1  kin of IRRE-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011238331.1

    Conserved Domains (6) summary
    cd05759
    Location:170251
    Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
    cd05898
    Location:439536
    Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
    smart00410
    Location:346437
    IG_like; Immunoglobulin like
    pfam07679
    Location:54148
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:340437
    Ig_2; Immunoglobulin domain
    cl11960
    Location:57148
    Ig; Immunoglobulin domain
  2. XM_006501076.3XP_006501139.1  kin of IRRE-like protein 1 isoform X2

    Conserved Domains (6) summary
    cd05759
    Location:143224
    Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
    cd05898
    Location:412509
    Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
    smart00410
    Location:319410
    IG_like; Immunoglobulin like
    pfam07679
    Location:27121
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:313410
    Ig_2; Immunoglobulin domain
    cl11960
    Location:30121
    Ig; Immunoglobulin domain
  3. XM_011240028.2XP_011238330.1  kin of IRRE-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011238330.1

    Conserved Domains (6) summary
    cd05759
    Location:170251
    Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
    cd05898
    Location:439536
    Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
    smart00410
    Location:346437
    IG_like; Immunoglobulin like
    pfam07679
    Location:54148
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:340437
    Ig_2; Immunoglobulin domain
    cl11960
    Location:57148
    Ig; Immunoglobulin domain
  4. XM_017319471.1XP_017174960.1  kin of IRRE-like protein 1 isoform X3

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