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XAGE5 X antigen family member 5 [ Homo sapiens (human) ]

Gene ID: 170627, updated on 12-Oct-2019

Summary

Official Symbol
XAGE5provided by HGNC
Official Full Name
X antigen family member 5provided by HGNC
Primary source
HGNC:HGNC:30930
See related
Ensembl:ENSG00000171405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT12.5; GAGED5; XAGE-5
Summary
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See XAGE5 in Genome Data Viewer
Location:
Xp11.22
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (52811295..52818298)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52840366..52847325)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene protein S100-A11 pseudogene Neighboring gene SPANX family member N5 Neighboring gene X antigen family member 3-like Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
X antigen family member 5
Names
G antigen, family D, 5
cancer/testis antigen 12.5
cancer/testis antigen family 12, member 5
g antigen family D member 5
protein XAGE-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130775.2NP_570131.1  X antigen family member 5

    See identical proteins and their annotated locations for NP_570131.1

    Status: REVIEWED

    Source sequence(s)
    BC069129, BC103962
    Consensus CDS
    CCDS14346.1
    UniProtKB/Swiss-Prot
    Q8WWM1
    UniProtKB/TrEMBL
    Q3SY49
    Related
    ENSP00000342240.1, ENST00000351072.5
    Conserved Domains (1) summary
    pfam05831
    Location:17105
    GAGE; GAGE protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    52811295..52818298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029320.2XP_016884809.1  X antigen family member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8WWM1
    Conserved Domains (1) summary
    pfam05831
    Location:17105
    GAGE; GAGE protein
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