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GPHA2 glycoprotein hormone subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 170589, updated on 12-Aug-2022

Summary

Official Symbol
GPHA2provided by HGNC
Official Full Name
glycoprotein hormone subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:18054
See related
Ensembl:ENSG00000149735 MIM:609651; AllianceGenome:HGNC:18054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A2; GPA2; ZSIG51
Summary
GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in pancreas (RPKM 14.6), testis (RPKM 3.2) and 2 other tissues See more
Orthologs
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Genomic context

See GPHA2 in Genome Data Viewer
Location:
11q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64934471..64937708, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64927724..64929150, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64701943..64703365, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene autophagy related 2A Neighboring gene microRNA 6750 Neighboring gene microRNA 6749 Neighboring gene protein phosphatase 2 regulatory subunit B'beta Neighboring gene membrane anchored junction protein Neighboring gene basic leucine zipper ATF-like transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thyrotropin-releasing hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thyrotropin-releasing hormone receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycoprotein hormone alpha-2
Names
cysteine knot protein
glycoprotein alpha 2
glycoprotein hormone alpha 2
putative secreted protein Zsig51
thyrostimulin subunit alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130769.4NP_570125.1  glycoprotein hormone alpha-2 precursor

    See identical proteins and their annotated locations for NP_570125.1

    Status: VALIDATED

    Source sequence(s)
    AF260739, AP001187
    Consensus CDS
    CCDS8086.1
    UniProtKB/Swiss-Prot
    Q52LE2, Q96T91
    UniProtKB/TrEMBL
    A0A024R579
    Related
    ENSP00000279168.2, ENST00000279168.7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64934471..64937708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544776.3XP_011543078.1  glycoprotein hormone alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_011543078.1

    UniProtKB/Swiss-Prot
    Q52LE2, Q96T91
    UniProtKB/TrEMBL
    A0A024R579
  2. XM_047426491.1XP_047282447.1  glycoprotein hormone alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    Q52LE2
    UniProtKB/TrEMBL
    A0A024R579

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64927724..64929150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)