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Fgf23 fibroblast growth factor 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170583, updated on 12-Mar-2019

Summary

Official Symbol
Fgf23provided by RGD
Official Full Name
fibroblast growth factor 23provided by RGD
Primary source
RGD:620178
See related
Ensembl:ENSRNOG00000052205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Thymus (RPKM 4.6), Spleen (RPKM 0.8) and 2 other tissues See more
Orthologs

Genomic context

See Fgf23 in Genome Data Viewer
Location:
4q42
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159622404..159630082)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (231971932..231990610, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 6 Neighboring gene uncharacterized LOC102547991 Neighboring gene TP53 induced glycolysis regulatory phosphatase Neighboring gene cyclin D2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor binding TAS
Traceable Author Statement
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
type 1 fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 1 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular phosphate ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to leptin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to parathyroid hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
phosphate-containing compound metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vitamin D 24-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
regulation of phosphate transport IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphate transport ISO
Inferred from Sequence Orthology
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to magnesium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to sodium phosphate IEP
Inferred from Expression Pattern
more info
PubMed 
vitamin D catabolic process IEA
Inferred from Electronic Annotation
more info
 
vitamin D catabolic process ISO
Inferred from Sequence Orthology
more info
 
vitamin D metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fibroblast growth factor 23
Names
FGF-23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130754.1NP_570110.1  fibroblast growth factor 23 precursor

    See identical proteins and their annotated locations for NP_570110.1

    Status: PROVISIONAL

    Source sequence(s)
    AB078777
    UniProtKB/Swiss-Prot
    Q8VI82
    Related
    ENSRNOP00000075536.1, ENSRNOT00000078299.1
    Conserved Domains (2) summary
    PHA03195
    Location:129226
    PHA03195; tegument protein VP11/12; Provisional
    cd00058
    Location:41160
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    159622404..159630082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    148629372..148637127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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