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Sp7 Sp7 transcription factor 7 [ Mus musculus (house mouse) ]

Gene ID: 170574, updated on 2-Oct-2018

Summary

Official Symbol
Sp7provided by MGI
Official Full Name
Sp7 transcription factor 7provided by MGI
Primary source
MGI:MGI:2153568
See related
Ensembl:ENSMUSG00000060284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C22; Osx; 6430578P22Rik
Expression
Biased expression in limb E14.5 (RPKM 8.9), frontal lobe adult (RPKM 5.1) and 5 other tissues See more
Orthologs

Genomic context

See Sp7 in Genome Data Viewer
Location:
15; 15 F3
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (102356606..102367040, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (102187608..102196702, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene achalasia, adrenocortical insufficiency, alacrimia Neighboring gene predicted gene, 36246 Neighboring gene trans-acting transcription factor 1 Neighboring gene anti-Mullerian hormone type 2 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130562

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor Sp7
Names
zinc finger protein osterix

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348205.1NP_001335134.1  transcription factor Sp7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK032521, AK077375, AY803733, BB375475
    UniProtKB/Swiss-Prot
    Q8VI67
    UniProtKB/TrEMBL
    Q5RM08
    Conserved Domains (3) summary
    sd00017
    Location:278297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:3229
    Atrophin-1; Atrophin-1 family
  2. NM_130458.4NP_569725.1  transcription factor Sp7 isoform 1

    See identical proteins and their annotated locations for NP_569725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK032521, AK076229, BB375475
    Consensus CDS
    CCDS37228.1
    UniProtKB/Swiss-Prot
    Q8VI67
    UniProtKB/TrEMBL
    Q2KHK9
    Related
    ENSMUSP00000077596.5, ENSMUST00000078508.6
    Conserved Domains (3) summary
    COG5048
    Location:306373
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:296315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:337362
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    102356606..102367040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520519.3XP_006520582.1  transcription factor Sp7 isoform X2

    See identical proteins and their annotated locations for XP_006520582.1

    UniProtKB/Swiss-Prot
    Q8VI67
    UniProtKB/TrEMBL
    Q2KHK9
    Conserved Domains (3) summary
    COG5048
    Location:306373
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:296315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:337362
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006520518.3XP_006520581.1  transcription factor Sp7 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:335402
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:366391
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006520520.3XP_006520583.1  transcription factor Sp7 isoform X3

    See identical proteins and their annotated locations for XP_006520583.1

    UniProtKB/TrEMBL
    Q5RM08
    Related
    ENSMUSP00000154859.1, ENSMUST00000229464.1
    Conserved Domains (3) summary
    sd00017
    Location:278297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:3229
    Atrophin-1; Atrophin-1 family
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