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HTR3C 5-hydroxytryptamine receptor 3C [ Homo sapiens (human) ]

Gene ID: 170572, updated on 2-Mar-2021

Summary

Official Symbol
HTR3Cprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 3Cprovided by HGNC
Primary source
HGNC:HGNC:24003
See related
Ensembl:ENSG00000178084 MIM:610121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HTR3C in Genome Data Viewer
Location:
3q27.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184053047..184060673)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183770835..183778461)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 8 Neighboring gene 5-hydroxytryptamine receptor 3D Neighboring gene EIF2B5 divergent transcript Neighboring gene 5-hydroxytryptamine receptor 3C2, pseudogene Neighboring gene HTR3E antisense RNA 1 Neighboring gene 5-hydroxytryptamine receptor 3E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A mega-analysis of genome-wide association studies for major depressive disorder.
GeneReviews: Not available
ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serotonin-gated cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin-gated cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5-hydroxytryptamine receptor 3C
Names
5-HT3-C
5-HT3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
5-hydroxytryptamine receptor 3 subunit C
serotonin receptor 3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012749.1 RefSeqGene

    Range
    5001..12627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130770.3NP_570126.2  5-hydroxytryptamine receptor 3C precursor

    See identical proteins and their annotated locations for NP_570126.2

    Status: REVIEWED

    Source sequence(s)
    AC131235
    Consensus CDS
    CCDS3250.1
    UniProtKB/Swiss-Prot
    Q8WXA8
    Related
    ENSP00000322617.1, ENST00000318351.2
    Conserved Domains (1) summary
    cl27321
    Location:43445
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    184053047..184060673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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