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Klrb1a killer cell lectin-like receptor subfamily B member 1A [ Mus musculus (house mouse) ]

Gene ID: 17057, updated on 26-Sep-2022

Summary

Official Symbol
Klrb1aprovided by MGI
Official Full Name
killer cell lectin-like receptor subfamily B member 1Aprovided by MGI
Primary source
MGI:MGI:107540
See related
Ensembl:ENSMUSG00000030361 AllianceGenome:MGI:107540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly55a; NKRP12; Nkrp1a; ly-55A; NKR-P1A; Nkrp1-a; NKR-P1.7
Summary
Predicted to enable carbohydrate binding activity. Located in plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 10.5), mammary gland adult (RPKM 0.9) and 1 other tissue See more
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Genomic context

See Klrb1a in Genome Data Viewer
Location:
6 F3; 6 63.06 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128586190..128599897, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128609227..128622934, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 8724 Neighboring gene alpha-2-macroglobulin like 1 Neighboring gene predicted gene, 44478 Neighboring gene target of myb1 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
killer cell lectin-like receptor subfamily B member 1A
Names
CD161 antigen-like family member A
NKR-P1 2
lymphocyte antigen 55 complex, locus A
lymphocyte antigen 55A
natural killer cell receptor protein NKR-P1A
natural killer cell receptor-P1
natural killer cell surface protein P1-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159902.1NP_001153374.1  killer cell lectin-like receptor subfamily B member 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC132352, BC120707, BC145045, M77676, M77753
    Consensus CDS
    CCDS51918.1
    UniProtKB/Swiss-Prot
    P27811
    UniProtKB/TrEMBL
    B7ZN67, E9Q0W1
    Related
    ENSMUSP00000132390.3, ENSMUST00000171306.5
    Conserved Domains (1) summary
    cd03593
    Location:67185
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_010737.3NP_034867.3  killer cell lectin-like receptor subfamily B member 1A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132352, BC120707, M77676, M77753
    Consensus CDS
    CCDS20574.2
    UniProtKB/Swiss-Prot
    P27811
    UniProtKB/TrEMBL
    G5E882
    Related
    ENSMUSP00000032512.9, ENSMUST00000032512.15
    Conserved Domains (2) summary
    cd03593
    Location:100218
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA03097
    Location:47221
    PHA03097; C-type lectin-like protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128586190..128599897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)