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DHX36 DEAH-box helicase 36 [ Homo sapiens (human) ]

Gene ID: 170506, updated on 9-Feb-2020

Summary

Official Symbol
DHX36provided by HGNC
Official Full Name
DEAH-box helicase 36provided by HGNC
Primary source
HGNC:HGNC:14410
See related
Ensembl:ENSG00000174953 MIM:612767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G4R1; RHAU; DDX36; MLEL1
Summary
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 24.2), thyroid (RPKM 15.5) and 25 other tissues See more
Orthologs

Genomic context

See DHX36 in Genome Data Viewer
Location:
3q25.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (154272546..154324497, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (153993452..154042286, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ARHGEF26 antisense RNA 1 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene uncharacterized LOC105374167 Neighboring gene Sharpr-MPRA regulatory region 7914 Neighboring gene G protein-coupled receptor 149 Neighboring gene DEAD-box helicase 50 pseudogene 2 Neighboring gene synaptophysin like 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, DEAH (Asp-Glu-Ala-His) box polypeptide 36 (DHX36), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with DHX36 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1488

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
G-quadruplex RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-quadruplex RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
G-quadruplex RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
N6-methyladenosine-containing RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
telomerase RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
G-quadruplex DNA unwinding IDA
Inferred from Direct Assay
more info
PubMed 
RNA secondary structure unwinding IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to arsenite ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardioblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hematopoietic progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interferon-alpha secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular mRNA localization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myeloid dendritic cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription initiation from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter involved in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
telomerase RNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ATP-dependent DNA/RNA helicase DHX36
Names
ATP-dependent RNA helicase DHX36
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36
DEAD/H box polypeptide 36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
DEAH box protein 36
G4 resolvase-1
MLE-like protein 1
RNA helicase associated with AU-rich element ARE
RNA helicase associated with AU-rich element protein
probable ATP-dependent RNA helicase DHX36
NP_001107869.1
NP_065916.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114397.1NP_001107869.1  ATP-dependent DNA/RNA helicase DHX36 isoform 2

    See identical proteins and their annotated locations for NP_001107869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 localizes to the cytoplasm.
    Source sequence(s)
    AJ577134, AK314435, BC036035
    Consensus CDS
    CCDS54657.1
    UniProtKB/Swiss-Prot
    Q9H2U1
    Related
    ENSP00000330113.5, ENST00000329463.9
    Conserved Domains (5) summary
    smart00487
    Location:210392
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:662746
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:224369
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:476592
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:786903
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  2. NM_020865.3NP_065916.2  ATP-dependent DNA/RNA helicase DHX36 isoform 1

    See identical proteins and their annotated locations for NP_065916.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Isoform 1 localizes to the nucleus and cytoplasm.
    Source sequence(s)
    AC018452, AK314435, BC036035
    Consensus CDS
    CCDS3171.1
    UniProtKB/Swiss-Prot
    Q9H2U1
    Related
    ENSP00000417078.1, ENST00000496811.6
    Conserved Domains (5) summary
    smart00487
    Location:210392
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:676760
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:224369
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:476606
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:800917
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    154272546..154324497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187533.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1179..9497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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