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CLEC4C C-type lectin domain family 4 member C [ Homo sapiens (human) ]

Gene ID: 170482, updated on 8-Jul-2021

Summary

Official Symbol
CLEC4Cprovided by HGNC
Official Full Name
C-type lectin domain family 4 member Cprovided by HGNC
Primary source
HGNC:HGNC:13258
See related
Ensembl:ENSG00000198178 MIM:606677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150
Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 1.5), spleen (RPKM 0.9) and 6 other tissues See more
Orthologs
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Genomic context

See CLEC4C in Genome Data Viewer
Location:
12p13.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (7729245..7751600, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7881979..7902137, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 3 Neighboring gene developmental pluripotency associated 3 Neighboring gene NANOG neighbor homeobox Neighboring gene NANOG 5' regulatory region Neighboring gene Nanog homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-mediated inhibition of IFN-alpha production involves CD4 and BDCA2 in plasmacytoid dendritic cells PubMed
env HIV-1 gp120 monomers and trimers bind to BDCA2 in transfected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125789, MGC125791, MGC125792, MGC125793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-type lectin domain family 4 member C
Names
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 7
C-type lectin superfamily member 7
blood dendritic cell antigen 2 protein
dendritic cell lectin b
dendritic lectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371390.1NP_001358319.1  C-type lectin domain family 4 member C isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006517, AY358223
    Related
    ENSP00000353500.3, ENST00000360345.8
    Conserved Domains (1) summary
    cd03590
    Location:83208
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  2. NM_001371391.1NP_001358320.1  C-type lectin domain family 4 member C isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006517
    Conserved Domains (1) summary
    cd03590
    Location:46171
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  3. NM_130441.3NP_569708.1  C-type lectin domain family 4 member C isoform 1

    See identical proteins and their annotated locations for NP_569708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).
    Source sequence(s)
    AC006517, AF293615
    Consensus CDS
    CCDS8583.1
    UniProtKB/Swiss-Prot
    Q8WTT0
    Related
    ENSP00000440428.1, ENST00000542353.5
    Conserved Domains (1) summary
    cd03590
    Location:83208
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  4. NM_203503.2NP_987099.1  C-type lectin domain family 4 member C isoform 2

    See identical proteins and their annotated locations for NP_987099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as DLEC-beta, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC006517, AF293615, AF325460
    Consensus CDS
    CCDS8584.1
    UniProtKB/Swiss-Prot
    Q8WTT0
    Related
    ENSP00000445338.1, ENST00000540085.5
    Conserved Domains (1) summary
    cd03590
    Location:52177
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    7729245..7751600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018940.2XP_016874429.1  C-type lectin domain family 4 member C isoform X2

  2. XM_024448872.1XP_024304640.1  C-type lectin domain family 4 member C isoform X1

    Conserved Domains (1) summary
    cd03590
    Location:83208
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  3. XM_024448873.1XP_024304641.1  C-type lectin domain family 4 member C isoform X1

    Conserved Domains (1) summary
    cd03590
    Location:83208
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
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