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meis1a Meis homeobox 1 a [ Danio rerio (zebrafish) ]

Gene ID: 170455, updated on 20-Feb-2026
Official Symbol
meis1aprovided by ZNC
Official Full Name
Meis homeobox 1 aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020122-3
See related
Ensembl:ENSDARG00000002937 AllianceGenome:ZFIN:ZDB-GENE-020122-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
meis4.1a; meis4.1b
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within brain development. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; nervous system; pectoral fin bud; pectoral fin musculature; and segmental plate. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See meis1a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 1 NC_133176.1 (54758066..54847520)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 1 NC_007112.7 (51479114..51525084)

Chromosome 1 - NC_133176.1Genomic Context describing neighboring genes Neighboring gene autophagy related 4D, cysteine peptidase a Neighboring gene actin related protein 2a Neighboring gene sprouty related EVH1 domain containing 2a Neighboring gene ETAA1 activator of ATR kinase a Neighboring gene protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Transcription factor Meis1b regulates craniofacial morphogenesis in zebrafish. Psutkova V, et al. Dev Dyn, 2025 Jan. PMID 39087648
  2. Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome. Schulte EC, et al. Am J Hum Genet, 2014 Jul 3. PMID 24995868, Free PMC Article
  3. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Amin S, et al. Dev Cell, 2015 Feb 9. PMID 25640223, Free PMC Article
  4. Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Xiao C, et al. Nat Commun, 2016 Dec 8. PMID 27929112, Free PMC Article
  5. Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Macaulay IC, et al. Cell Rep, 2016 Feb 2. PMID 26804912, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
homeobox protein Meis1a
Names
myeloid ecotropic viral integration site 4.1a
myeloid ecotropic viral integration site 4.1b

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131897.2 → NP_571972.2  homeobox protein Meis1a

    See identical proteins and their annotated locations for NP_571972.2

    Status: PROVISIONAL

    Source sequence(s)
    BC056317
    UniProtKB/TrEMBL
    A0A8M1PCH5, Q7SZP3
    Related
    ENSDARP00000026780.9, ENSDART00000028018.11
    Conserved Domains (2) summary
    pfam05920
    Location:279 → 318
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99 → 182
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133176.1 Reference GRCz12tu Primary Assembly

    Range
    54758066..54847520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073952373.1 → XP_073808474.1  homeobox protein Meis1a isoform X3

    UniProtKB/TrEMBL
    A0AC58JPR0, A0AC58JPR8

  2. XM_073952383.1 → XP_073808484.1  homeobox protein Meis1a isoform X3

    UniProtKB/TrEMBL
    A0AC58JPR0, A0AC58JPR8

  3. XM_073952385.1 → XP_073808486.1  homeobox protein Meis1a isoform X4

    UniProtKB/TrEMBL
    A0AC58JPR3, A0AC58JPW2

  4. XM_073952387.1 → XP_073808488.1  homeobox protein Meis1a isoform X4

    UniProtKB/TrEMBL
    A0AC58JPR3, A0AC58JPW2

  5. XM_073952397.1 → XP_073808498.1  homeobox protein Meis1a isoform X5

    UniProtKB/TrEMBL
    A0AC58JPU3, A0AC58JPW5

  6. XM_073952422.1 → XP_073808523.1  homeobox protein Meis1a isoform X5

    UniProtKB/TrEMBL
    A0AC58JPU3, A0AC58JPW5

  7. XM_073952456.1 → XP_073808557.1  homeobox protein Meis1a isoform X6

    UniProtKB/TrEMBL
    A0AC58JPZ7, A0AC58JQ47

  8. XM_073952506.1 → XP_073808607.1  homeobox protein Meis1a isoform X6

    UniProtKB/TrEMBL
    A0AC58JPZ7, A0AC58JQ47

  9. XM_005160124.5 → XP_005160181.1  homeobox protein Meis1a isoform X1

    See identical proteins and their annotated locations for XP_005160181.1

    UniProtKB/TrEMBL
    A0A8M1PCH5, Q7SZP3
    Conserved Domains (2) summary
    pfam05920
    Location:279 → 318
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99 → 182
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  10. XM_005160125.4 → XP_005160182.1  homeobox protein Meis1a isoform X2

    UniProtKB/TrEMBL
    A0A8M2B7B4, A0AC58JPN0
    Conserved Domains (2) summary
    pfam05920
    Location:279 → 318
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:99 → 182
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  11. XM_073952336.1 → XP_073808437.1  homeobox protein Meis1a isoform X2

    UniProtKB/TrEMBL
    A0A8M2B7B4, A0AC58JPN0
Nucleotide Protein Strain
Heading Accession and Version

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