OIT3 oncoprotein induced transcript 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OIT3provided by HGNC
Official Full Name: oncoprotein induced transcript 3provided by HGNC
Primary source: HGNC:HGNC:29953
See related: Ensembl:ENSG00000138315 MIM:609330; AllianceGenome:HGNC:29953
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LZP
Summary: This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]
Expression: Biased expression in liver (RPKM 29.6), small intestine (RPKM 2.8) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (72893739..72933036)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (73765121..73804414)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (74653497..74692794)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.
Title: OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.
rs554643826 (T439S) may have contributed to inheritance of gout in a Chinese family
Title: Gout inheritance in an extended Chinese family analyzed by whole-exome sequencing: A case-report.
Loss of heterozygosity of OIT3 gene on chromosome 10q is associated with pancreatic cancer.
Title: Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer.
The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens.
Title: Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules.
D8C, a novel domain present in LZP, mutates in familial juvenile hyperuricemia.
Title: Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy.
Liver-specific ZP domain-containing protein (LZP) is a liver-specific protein involved possibly in hepatocellular function and development. (liver-specific ZP domain-containing protein)
Title: A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70386 (e-PCR)
- UniSTS:75537

NoName (e-PCR)
- UniSTS:486006

RH81037 (e-PCR)
- UniSTS:92797

D10S1146 (e-PCR)
- UniSTS:149154

D10S1432 (e-PCR), detects polymorphism
- UniSTS:27129

Homology

Homologs of the OIT3 gene: The OIT3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 476 organisms have orthologs with human gene OIT3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in urate homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oncoprotein-induced transcript 3 protein

Names: liver-specific ZP domain-containing protein; liver-specific zona pellucida domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051614.1 RefSeqGene

Range

5184..44481

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_152635.3 → NP_689848.1 oncoprotein-induced transcript 3 protein precursor

See identical proteins and their annotated locations for NP_689848.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.

Source sequence(s)

AC069548, AY358339

Consensus CDS

CCDS7318.1

UniProtKB/Swiss-Prot

Q8N1M8, Q8WWZ8

Related

ENSP00000333900.5, ENST00000334011.10

Conserved Domains (3) summary

smart00241
Location:268 → 513

ZP; Zona pellucida (ZP) domain

pfam00100
Location:394 → 513

Zona_pellucida; Zona pellucida-like domain

pfam14670
Location:227 → 262

FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

NR_130125.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC069548, AY358339, BC126440