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OIT3 oncoprotein induced transcript 3 [ Homo sapiens (human) ]

Gene ID: 170392, updated on 7-Jun-2020

Summary

Official Symbol
OIT3provided by HGNC
Official Full Name
oncoprotein induced transcript 3provided by HGNC
Primary source
HGNC:HGNC:29953
See related
Ensembl:ENSG00000138315 MIM:609330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZP
Summary
This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]
Expression
Biased expression in liver (RPKM 29.6), small intestine (RPKM 2.8) and 3 other tissues See more
Orthologs

Genomic context

See OIT3 in Genome Data Viewer
Location:
10q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (72893739..72933036)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (74653339..74692787)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 34 Neighboring gene mitochondrial calcium uniporter Neighboring gene microRNA 4676 Neighboring gene nucleophosmin 1 pseudogene 24 Neighboring gene phospholipase A2 group XIIB Neighboring gene ribosomal protein L17 pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
urate homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
oncoprotein-induced transcript 3 protein
Names
liver-specific ZP domain-containing protein
liver-specific zona pellucida domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051614.1 RefSeqGene

    Range
    5184..44481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152635.3NP_689848.1  oncoprotein-induced transcript 3 protein precursor

    See identical proteins and their annotated locations for NP_689848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC069548, AY358339
    Consensus CDS
    CCDS7318.1
    UniProtKB/Swiss-Prot
    Q8WWZ8
    Related
    ENSP00000333900.5, ENST00000334011.10
    Conserved Domains (3) summary
    smart00241
    Location:268513
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:394513
    Zona_pellucida; Zona pellucida-like domain
    pfam14670
    Location:227262
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. NR_130125.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC069548, AY358339, BC126440

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    72893739..72933036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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