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OIT3 oncoprotein induced transcript 3 [ Homo sapiens (human) ]

Gene ID: 170392, updated on 7-Sep-2023

Summary

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Official Symbol
OIT3provided by HGNC
Official Full Name
oncoprotein induced transcript 3provided by HGNC
Primary source
HGNC:HGNC:29953
See related
Ensembl:ENSG00000138315 MIM:609330; AllianceGenome:HGNC:29953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZP
Summary
This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]
Expression
Biased expression in liver (RPKM 29.6), small intestine (RPKM 2.8) and 3 other tissues See more
Orthologs
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Genomic context

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See OIT3 in Genome Data Viewer
Location:
10q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (72893739..72933036)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (73765121..73804414)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (74653497..74692794)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uniporter Neighboring gene microRNA 4676 Neighboring gene uncharacterized LOC124902450 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:74516687-74517186 Neighboring gene Sharpr-MPRA regulatory region 7737 Neighboring gene Sharpr-MPRA regulatory region 6662 Neighboring gene Sharpr-MPRA regulatory region 12879 Neighboring gene nucleophosmin 1 pseudogene 24 Neighboring gene uncharacterized LOC124902451 Neighboring gene phospholipase A2 group XIIB Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74741016-74741516 Neighboring gene ribosomal protein L17 pseudogene 50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression. Yang S, et al. Cancer Immunol Immunother, 2022 Nov. PMID 35353239
  2. Increased OIT3 in macrophages promotes PD-L1 expression and hepatocellular carcinogenesis via NF-κB signaling. Wen J, et al. Exp Cell Res, 2023 Jul 15. PMID 37201744
  3. Gout inheritance in an extended Chinese family analyzed by whole-exome sequencing: A case-report. Yang P, et al. Medicine (Baltimore), 2020 Jun 19. PMID 32569156, Free PMC Article
  4. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. Yang H, et al. FEBS Lett, 2004 Dec 17. PMID 15589826
  5. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Xu ZG, et al. Hepatology, 2003 Sep. PMID 12939600

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased OIT3 in macrophages promotes PD-L1 expression and hepatocellular carcinogenesis via NF-kappaB signaling.
    Title: Increased OIT3 in macrophages promotes PD-L1 expression and hepatocellular carcinogenesis via NF-κB signaling.
  2. OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.
    Title: OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.
  3. rs554643826 (T439S) may have contributed to inheritance of gout in a Chinese family
    Title: Gout inheritance in an extended Chinese family analyzed by whole-exome sequencing: A case-report.
  4. Loss of heterozygosity of OIT3 gene on chromosome 10q is associated with pancreatic cancer.
    Title: Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer.
  5. The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens.
    Title: Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules.
  6. D8C, a novel domain present in LZP, mutates in familial juvenile hyperuricemia.
    Title: Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy.
  7. Liver-specific ZP domain-containing protein (LZP) is a liver-specific protein involved possibly in hepatocellular function and development. (liver-specific ZP domain-containing protein)
    Title: A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in renal system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
oncoprotein-induced transcript 3 protein
Names
liver-specific ZP domain-containing protein
liver-specific zona pellucida domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051614.1 RefSeqGene

    Range
    5184..44481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152635.3 → NP_689848.1  oncoprotein-induced transcript 3 protein precursor

    See identical proteins and their annotated locations for NP_689848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC069548, AY358339
    Consensus CDS
    CCDS7318.1
    UniProtKB/Swiss-Prot
    A0AVP3, Q8N1M8, Q8WWZ8
    Related
    ENSP00000333900.5, ENST00000334011.10
    Conserved Domains (3) summary
    smart00241
    Location:268 → 513
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:394 → 513
    Zona_pellucida; Zona pellucida-like domain
    pfam14670
    Location:227 → 262
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. NR_130125.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC069548, AY358339, BC126440

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    72893739..72933036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    73765121..73804414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWZ8.2 GenPept UniProtKB/Swiss-Prot:Q8WWZ8

Gene LinkOut

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