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TMEM273 transmembrane protein 273 [ Homo sapiens (human) ]

Gene ID: 170371, updated on 23-Nov-2021

Summary

Official Symbol
TMEM273provided by HGNC
Official Full Name
transmembrane protein 273provided by HGNC
Primary source
HGNC:HGNC:27274
See related
Ensembl:ENSG00000204161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf128
Expression
Ubiquitous expression in fat (RPKM 4.4), spleen (RPKM 4.0) and 24 other tissues See more
Orthologs
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Genomic context

See TMEM273 in Genome Data Viewer
Location:
10q11.23
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49154728..49188580, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50362781..50396436, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 4 Neighboring gene FAM170B antisense RNA 1 Neighboring gene family with sequence similarity 170 member B Neighboring gene C10orf71 antisense RNA 1 Neighboring gene chromosome 10 open reading frame 71 Neighboring gene dorsal root ganglia homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ52649

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010863.4NP_001010863.1  transmembrane protein 273 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001010863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC031641, BC047724, BC104438, CA396219
    Consensus CDS
    CCDS41519.1
    UniProtKB/Swiss-Prot
    Q5T292
    Related
    ENSP00000417246.1, ENST00000474718.5
    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  2. NM_001288740.3NP_001275669.1  transmembrane protein 273 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001275669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus.
    Source sequence(s)
    AL524299, BC031641, BC047724, CA396219
    Consensus CDS
    CCDS73128.1
    UniProtKB/Swiss-Prot
    Q5T292
    Related
    ENSP00000363268.1, ENST00000374153.7
    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  3. NM_001288741.3NP_001275670.1  transmembrane protein 273 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC031641, BC047724, CA396219, DA366138
    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  4. NM_001288742.3NP_001275671.1  transmembrane protein 273 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001275671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the central coding region, which results in a frameshift, and uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (4) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC031641, BC047724, BU145920, CA396219
    Related
    ENSP00000395067.1, ENST00000453436.5
    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  5. NM_001288743.3NP_001275672.1  transmembrane protein 273 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001275672.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the central coding region, which results in a frameshift, and uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (5) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC031641, BC047724, BU145920, CA396219, DQ884399
    UniProtKB/Swiss-Prot
    Q5T292
    Related
    ENSP00000363266.4, ENST00000374151.7
    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  6. NM_001353330.2NP_001340259.1  transmembrane protein 273 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084727, AL441885
    Related
    ENSP00000363263.1, ENST00000374148.1
    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  7. NM_001353331.2NP_001340260.1  transmembrane protein 273 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084727, AL441885
    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49154728..49188580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015797.1XP_016871286.1  transmembrane protein 273 isoform X10

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  2. XM_011539385.1XP_011537687.1  transmembrane protein 273 isoform X11

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  3. XM_017015794.1XP_016871283.1  transmembrane protein 273 isoform X6

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  4. XM_011539384.1XP_011537686.1  transmembrane protein 273 isoform X7

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  5. XM_017015793.1XP_016871282.1  transmembrane protein 273 isoform X4

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  6. XM_017015792.1XP_016871281.1  transmembrane protein 273 isoform X1

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  7. XM_011539379.1XP_011537681.1  transmembrane protein 273 isoform X3

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  8. XM_024447853.1XP_024303621.1  transmembrane protein 273 isoform X12

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  9. XM_011539382.1XP_011537684.1  transmembrane protein 273 isoform X5

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  10. XM_011539378.2XP_011537680.1  transmembrane protein 273 isoform X2

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  11. XM_017015796.1XP_016871285.1  transmembrane protein 273 isoform X9

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)
  12. XM_017015795.1XP_016871284.1  transmembrane protein 273 isoform X8

    Conserved Domains (1) summary
    pfam14986
    Location:1574
    DUF4514; Domain of unknown function (DUF4514)

RNA

  1. XR_002956963.1 RNA Sequence

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