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Ltf lactotransferrin [ Mus musculus (house mouse) ]

Gene ID: 17002, updated on 24-Jan-2023

Summary

Official Symbol
Ltfprovided by MGI
Official Full Name
lactotransferrinprovided by MGI
Primary source
MGI:MGI:96837
See related
Ensembl:ENSMUSG00000032496 AllianceGenome:MGI:96837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lf; Csp82; Ms10r; MMS10R
Summary
Enables peptidase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of hydrolase activity; and regulation of signal transduction. Predicted to act upstream of or within several processes, including iron ion homeostasis; ossification; and proteolysis. Located in cytoplasm. Is expressed in several structures, including early conceptus; epithelium; genitourinary system; immune system; and liver. Human ortholog(s) of this gene implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human LTF (lactotransferrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 57.9), ovary adult (RPKM 22.0) and 6 other tissues See more
Orthologs
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Genomic context

See Ltf in Genome Data Viewer
Location:
9 F2; 9 60.79 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110848360..110871834)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111019292..111042766)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 2 Neighboring gene predicted gene 10030 Neighboring gene receptor transporter protein 3 Neighboring gene chemokine (C-C motif) receptor-like 2 Neighboring gene ribosomal protein L31, pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antifungal humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in bone morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in disruption by host of symbiont membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of single-species biofilm formation in or on host organism ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in specific granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lactotransferrin
Names
N lobe
lactoferrin
minisatellite 10r detected by probe MMS10
NP_032548.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008522.3NP_032548.2  lactotransferrin precursor

    See identical proteins and their annotated locations for NP_032548.2

    Status: VALIDATED

    Source sequence(s)
    AK036491
    Consensus CDS
    CCDS23581.1
    UniProtKB/Swiss-Prot
    P08071, Q922P2
    Related
    ENSMUSP00000035077.4, ENSMUST00000035077.8
    Conserved Domains (4) summary
    smart00094
    Location:363692
    TR_FER; Transferrin
    cd13617
    Location:361691
    PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    cd13618
    Location:23349
    PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    pfam00405
    Location:24351
    Transferrin; Transferrin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110848360..110871834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)