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TENT5D terminal nucleotidyltransferase 5D [ Homo sapiens (human) ]

Gene ID: 169966, updated on 1-Aug-2020

Summary

Official Symbol
TENT5Dprovided by HGNC
Official Full Name
terminal nucleotidyltransferase 5Dprovided by HGNC
Primary source
HGNC:HGNC:28399
See related
Ensembl:ENSG00000174016 MIM:300976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT112; CT1.26; FAM46D
Summary
Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009]
Expression
Restricted expression toward testis (RPKM 2.2) See more
Orthologs

Genomic context

See TENT5D in Genome Data Viewer
Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (80335439..80446885)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (79591003..79700810)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TBX22 P0 promoter Neighboring gene T-box transcription factor 22 Neighboring gene charged multivesicular body protein 1B2, pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein H3 pseudogene 1 Neighboring gene WBP11 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26999

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
terminal nucleotidyltransferase 5D
Names
cancer/testis antigen 112
family with sequence similarity 46 member D
non-canonical poly(A) polymerase FAM46D
protein FAM46D
putative nucleotidyltransferase FAM46D
NP_001164045.1
NP_689843.1
XP_024308112.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016384.2 RefSeqGene

    Range
    89944..114808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170574.1NP_001164045.1  terminal nucleotidyltransferase 5D

    See identical proteins and their annotated locations for NP_001164045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK128147, BC030784
    Consensus CDS
    CCDS14446.1
    UniProtKB/Swiss-Prot
    Q8NEK8
    Related
    ENSP00000443410.1, ENST00000538312.5
    Conserved Domains (1) summary
    pfam07984
    Location:9327
    NTP_transf_7; Nucleotidyltransferase
  2. NM_152630.4NP_689843.1  terminal nucleotidyltransferase 5D

    See identical proteins and their annotated locations for NP_689843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC030784, BX506299
    Consensus CDS
    CCDS14446.1
    UniProtKB/Swiss-Prot
    Q8NEK8
    Related
    ENSP00000308575.5, ENST00000308293.5
    Conserved Domains (1) summary
    pfam07984
    Location:9327
    NTP_transf_7; Nucleotidyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    80335439..80446885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452344.1XP_024308112.1  terminal nucleotidyltransferase 5D isoform X1

    Conserved Domains (1) summary
    pfam07984
    Location:9327
    NTP_transf_7; Nucleotidyltransferase
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