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Ltb lymphotoxin B [ Mus musculus (house mouse) ]

Gene ID: 16994, updated on 9-Dec-2022

Summary

Official Symbol
Ltbprovided by MGI
Official Full Name
lymphotoxin Bprovided by MGI
Primary source
MGI:MGI:104796
See related
Ensembl:ENSMUSG00000024399 AllianceGenome:MGI:104796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p33; Tnfc; LTbeta; Tnfsf3; Tnlg1c
Summary
Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in positive regulation of interleukin-12 production. Acts upstream of or within gene expression; lymph node development; and skin development. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; hemolymphoid system; liver; lung; and reproductive system. Orthologous to human LTB (lymphotoxin beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 307.1), thymus adult (RPKM 119.5) and 1 other tissue See more
Orthologs
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Genomic context

See Ltb in Genome Data Viewer
Location:
17 B1; 17 18.59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35413483..35415281)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35194507..35196305)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene natural cytotoxicity triggering receptor 3, pseudogene Neighboring gene leukocyte specific transcript 1 Neighboring gene microRNA 6973a Neighboring gene tumor necrosis factor Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
lymphotoxin-beta
Names
LT-beta
TNF-C
tumor necrosis factor C
tumor necrosis factor ligand 1c
tumor necrosis factor ligand superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008518.2NP_032544.1  lymphotoxin-beta

    See identical proteins and their annotated locations for NP_032544.1

    Status: VALIDATED

    Source sequence(s)
    BC064062, CR974444, U16985
    Consensus CDS
    CCDS28690.1
    UniProtKB/Swiss-Prot
    P41155
    UniProtKB/TrEMBL
    A0A0U5JAA2
    Related
    ENSMUSP00000025262.6, ENSMUST00000025262.6
    Conserved Domains (1) summary
    cd00184
    Location:154303
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35413483..35415281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)