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Zbtb7a zinc finger and BTB domain containing 7a [ Mus musculus (house mouse) ]

Gene ID: 16969, updated on 26-Sep-2022

Summary

Official Symbol
Zbtb7aprovided by MGI
Official Full Name
zinc finger and BTB domain containing 7aprovided by MGI
Primary source
MGI:MGI:1335091
See related
Ensembl:ENSMUSG00000035011 AllianceGenome:MGI:1335091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrf; FBI-1; Zbtb7; Pokemon; 9030619K07Rik; 9130006G12Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Involved in several processes, including hemopoiesis; nucleic acid metabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Part of DNA-dependent protein kinase complex. Colocalizes with site of double-strand break. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human ZBTB7A (zinc finger and BTB domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 50.1), adrenal adult (RPKM 36.3) and 23 other tissues See more
Orthologs
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Genomic context

See Zbtb7a in Genome Data Viewer
Location:
10; 10 C1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80970416..80988056)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81135225..81152222)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 5615-1 Neighboring gene microRNA 5615-2 Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cartilage development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via classical nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
involved_in erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA-dependent protein kinase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of DNA-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 7A
Names
POK erythroid myeloid ontogenic factor
POZ and Krueppel erythroid myeloid ontogenic factor
leukemia/lymphoma related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404861.1NP_001391790.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    Q9CRJ0
  2. NM_001404862.1NP_001391791.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    Q9CRJ0
  3. NM_001404863.1NP_001391792.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    Q9CRJ0
  4. NM_001404864.1NP_001391793.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    Q9CRJ0
  5. NM_001404865.1NP_001391794.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    Q9CRJ0
  6. NM_001404866.1NP_001391795.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    Q9CRJ0
  7. NM_001404867.1NP_001391796.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    Q9CRJ0
  8. NM_010731.4NP_034861.3  zinc finger and BTB domain-containing protein 7A

    See identical proteins and their annotated locations for NP_034861.3

    Status: VALIDATED

    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS35991.1
    UniProtKB/Swiss-Prot
    O88939, Q9CRJ0
    Related
    ENSMUSP00000047333.9, ENSMUST00000048128.15
    Conserved Domains (3) summary
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:419443
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80970416..80988056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513279.3XP_006513342.3  zinc finger and BTB domain-containing protein 7A isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:562582
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:165284
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:575599
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006513280.5XP_006513343.2  zinc finger and BTB domain-containing protein 7A isoform X2

    UniProtKB/Swiss-Prot
    O88939
    Conserved Domains (3) summary
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:419443
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006513282.3XP_006513345.1  zinc finger and BTB domain-containing protein 7A isoform X2

    UniProtKB/Swiss-Prot
    O88939
    Related
    ENSMUSP00000113612.2, ENSMUST00000119606.8
    Conserved Domains (3) summary
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:419443
    zf-H2C2_2; Zinc-finger double domain
  4. XM_030244921.1XP_030100781.1  zinc finger and BTB domain-containing protein 7A isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:419443
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006513281.5XP_006513344.1  zinc finger and BTB domain-containing protein 7A isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:485505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:88207
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:498522
    zf-H2C2_2; Zinc-finger double domain