Zbtb7a zinc finger and BTB domain containing 7a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb7aprovided by MGI
Official Full Name: zinc finger and BTB domain containing 7aprovided by MGI
Primary source: MGI:MGI:1335091
See related: Ensembl:ENSMUSG00000035011 AllianceGenome:MGI:1335091
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrf; FBI-1; Zbtb7; Pokemon; 9030619K07Rik; 9130006G12Rik
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Involved in several processes, including hemopoiesis; nucleic acid metabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Part of DNA-dependent protein kinase complex. Colocalizes with site of double-strand break. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human ZBTB7A (zinc finger and BTB domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 50.1), adrenal adult (RPKM 36.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 C1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80970416..80988056)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81135225..81152222)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68.
Title: Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68.
Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1.
Title: Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1.
Intragenic antagonistic roles of protein and circRNA in tumorigenesis.
Title: Intragenic antagonistic roles of protein and circRNA in tumorigenesis.
widely used promoter factor that transduces signals from other transcription factors to enable control of accessibility and regulation of gene expression
Title: Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.
LRF is expressed mainly in oligodendrocytes but is not required for oligodendrocyte repopulation of demyelinated lesions. Furthermore, LRF can modulate the extent of remyelination, potentially by contributing to interactions regulating transcription
Title: Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination.
Alveolar macrophages deficient in Zbtb7a failed to induce antibody and T cell responses.
Title: Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.
this study shows that Thpok and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool
Title: Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.
This study identified Zbtb7a as a novel direct target for miR-125a by gene expression profiling in miR-125a knockout mice combined with bioinformatics target prediction, and elucidated the role of Zbtb7a in oncogenesis.
Title: A Zbtb7a proto-oncogene as a novel target for miR-125a.
This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair.
Title: LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells.
Title: Attenuation of Leukemia/Lymphoma-Related Factor Protein Expression Inhibits Glioma Cell Proliferation and Invasion.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Zbtb7a gene: The Zbtb7a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 320 organisms have orthologs with human gene Zbtb7a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via classical nonhomologous end joining	IDA Inferred from Direct Assay more info	PubMed
involved_in erythrocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA-dependent protein kinase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of DNA-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 7A

Names: POK erythroid myeloid ontogenic factor; POZ and Krueppel erythroid myeloid ontogenic factor; leukemia/lymphoma related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404861.1 → NP_001391790.1 zinc finger and BTB domain-containing protein 7A

Status: VALIDATED

Source sequence(s)

AC155932

UniProtKB/Swiss-Prot

Q9CRJ0
NM_001404862.1 → NP_001391791.1 zinc finger and BTB domain-containing protein 7A

Status: VALIDATED

Source sequence(s)

AC155932

UniProtKB/Swiss-Prot

Q9CRJ0
NM_001404863.1 → NP_001391792.1 zinc finger and BTB domain-containing protein 7A

Status: VALIDATED

Source sequence(s)

AC155932

UniProtKB/Swiss-Prot

Q9CRJ0
NM_001404864.1 → NP_001391793.1 zinc finger and BTB domain-containing protein 7A

Status: VALIDATED

Source sequence(s)

AC155932

UniProtKB/Swiss-Prot

Q9CRJ0
NM_001404865.1 → NP_001391794.1 zinc finger and BTB domain-containing protein 7A

Status: VALIDATED

Source sequence(s)

AC155932

UniProtKB/Swiss-Prot

Q9CRJ0
NM_001404866.1 → NP_001391795.1 zinc finger and BTB domain-containing protein 7A

Status: VALIDATED

Source sequence(s)

AC155932

UniProtKB/Swiss-Prot

Q9CRJ0
NM_001404867.1 → NP_001391796.1 zinc finger and BTB domain-containing protein 7A

Status: VALIDATED

Source sequence(s)

AC155932

UniProtKB/Swiss-Prot

Q9CRJ0
NM_010731.4 → NP_034861.3 zinc finger and BTB domain-containing protein 7A

See identical proteins and their annotated locations for NP_034861.3

Status: VALIDATED

Source sequence(s)

AC155932

Consensus CDS

CCDS35991.1

UniProtKB/Swiss-Prot

O88939, Q9CRJ0

Related

ENSMUSP00000047333.9, ENSMUST00000048128.15

Conserved Domains (3) summary

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:9 → 128

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:419 → 443

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80970416..80988056

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513279.3 → XP_006513342.3 zinc finger and BTB domain-containing protein 7A isoform X1

Conserved Domains (3) summary

sd00017
Location:562 → 582

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:165 → 284

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:575 → 599

zf-H2C2_2; Zinc-finger double domain
XM_006513280.5 → XP_006513343.2 zinc finger and BTB domain-containing protein 7A isoform X2

UniProtKB/Swiss-Prot

O88939

Conserved Domains (3) summary

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:9 → 128

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:419 → 443

zf-H2C2_2; Zinc-finger double domain
XM_006513282.3 → XP_006513345.1 zinc finger and BTB domain-containing protein 7A isoform X2

UniProtKB/Swiss-Prot

O88939

Related

ENSMUSP00000113612.2, ENSMUST00000119606.8

Conserved Domains (3) summary

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:9 → 128

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:419 → 443

zf-H2C2_2; Zinc-finger double domain
XM_030244921.1 → XP_030100781.1 zinc finger and BTB domain-containing protein 7A isoform X2

Conserved Domains (3) summary

sd00017
Location:406 → 426

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:9 → 128

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:419 → 443

zf-H2C2_2; Zinc-finger double domain
XM_006513281.5 → XP_006513344.1 zinc finger and BTB domain-containing protein 7A isoform X3

Conserved Domains (3) summary

sd00017
Location:485 → 505

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18326
Location:88 → 207

BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)

pfam13465
Location:498 → 522

zf-H2C2_2; Zinc-finger double domain