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OLFML2A olfactomedin like 2A [ Homo sapiens (human) ]

Gene ID: 169611, updated on 1-Jun-2020

Summary

Official Symbol
OLFML2Aprovided by HGNC
Official Full Name
olfactomedin like 2Aprovided by HGNC
Primary source
HGNC:HGNC:27270
See related
Ensembl:ENSG00000185585 MIM:615899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO34319
Expression
Broad expression in spleen (RPKM 18.8), endometrium (RPKM 12.2) and 20 other tissues See more
Orthologs

Genomic context

See OLFML2A in Genome Data Viewer
Location:
9q33.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124777133..124814891)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127539435..127577161)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene MIR181A2 host gene Neighboring gene microRNA 181b-2 Neighboring gene uncharacterized LOC107987126 Neighboring gene WD repeat domain 38 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene ribosomal protein L35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactomedin-like protein 2A
Names
photomedin-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282715.1NP_001269644.1  olfactomedin-like protein 2A isoform 2

    See identical proteins and their annotated locations for NP_001269644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' structure compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI141934, AL354928, BC054001
    Consensus CDS
    CCDS65129.1
    UniProtKB/Swiss-Prot
    Q68BL7
    Related
    ENSP00000288815.5, ENST00000288815.5
    Conserved Domains (1) summary
    pfam02191
    Location:185434
    OLF; Olfactomedin-like domain
  2. NM_182487.4NP_872293.2  olfactomedin-like protein 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_872293.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB119055, AL354928, DA727926
    Consensus CDS
    CCDS6857.2
    UniProtKB/Swiss-Prot
    Q68BL7
    Related
    ENSP00000362682.3, ENST00000373580.8
    Conserved Domains (1) summary
    pfam02191
    Location:399648
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    124777133..124814891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251760.5XP_005251817.1  olfactomedin-like protein 2A isoform X2

    Conserved Domains (1) summary
    pfam02191
    Location:316565
    OLF; Olfactomedin-like domain
  2. XM_006716989.2XP_006717052.1  olfactomedin-like protein 2A isoform X1

    Conserved Domains (1) summary
    pfam02191
    Location:363612
    OLF; Olfactomedin-like domain
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