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SNX31 sorting nexin 31 [ Homo sapiens (human) ]

Gene ID: 169166, updated on 23-Nov-2021

Summary

Official Symbol
SNX31provided by HGNC
Official Full Name
sorting nexin 31provided by HGNC
Primary source
HGNC:HGNC:28605
See related
Ensembl:ENSG00000174226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in urinary bladder (RPKM 11.1), esophagus (RPKM 2.0) and 2 other tissues See more
Orthologs
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Genomic context

See SNX31 in Genome Data Viewer
Location:
8q22.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (100572874..100663410, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101585102..101661893, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 46 Neighboring gene Sharpr-MPRA regulatory region 13822 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 62 Neighboring gene uncharacterized LOC105375671 Neighboring gene uncharacterized LOC105375672 Neighboring gene RNA, U6 small nuclear 1092, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies SNX31, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39715

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363720.1NP_001350649.1  sorting nexin-31 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK093906, AP000424, AP001205, BC031260, DB312716
    Consensus CDS
    CCDS87622.1
    Related
    ENSP00000405024.2, ENST00000428383.6
    Conserved Domains (2) summary
    cd13336
    Location:171285
    FERM-like_C_SNX31; Atypical FERM-like domain C-lobe of Sorting nexin 31
    cl09511
    Location:22152
    FERM_B-lobe; FERM domain B-lobe
  2. NM_152628.4NP_689841.3  sorting nexin-31 isoform 1

    See identical proteins and their annotated locations for NP_689841.3

    Status: VALIDATED

    Source sequence(s)
    AK093906, AP001205, BQ012274, CD106024
    Consensus CDS
    CCDS6288.1
    UniProtKB/Swiss-Prot
    Q8N9S9
    Related
    ENSP00000312368.2, ENST00000311812.7
    Conserved Domains (3) summary
    cd06885
    Location:4106
    PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
    cd13336
    Location:270384
    FERM-like_C_SNX31; Atypical FERM-like domain C-lobe of Sorting nexin 31
    cl00155
    Location:119204
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    100572874..100663410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516899.1XP_011515201.1  sorting nexin-31 isoform X8

    Conserved Domains (3) summary
    cd13336
    Location:204318
    FERM-like_C_SNX31; Atypical FERM-like domain C-lobe of Sorting nexin 31
    cl00155
    Location:53138
    UBQ; Ubiquitin-like proteins
    cl02563
    Location:140
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_024447085.1XP_024302853.1  sorting nexin-31 isoform X13

    Conserved Domains (2) summary
    cd06885
    Location:4106
    PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
    cd13336
    Location:187301
    FERM-like_C_SNX31; Atypical FERM-like domain C-lobe of Sorting nexin 31
  3. XM_017013161.1XP_016868650.1  sorting nexin-31 isoform X10

  4. XM_017013162.1XP_016868651.1  sorting nexin-31 isoform X14

  5. XM_017013160.1XP_016868649.1  sorting nexin-31 isoform X9

  6. XM_017013159.1XP_016868648.1  sorting nexin-31 isoform X7

  7. XM_017013158.1XP_016868647.1  sorting nexin-31 isoform X6

  8. XM_017013157.1XP_016868646.1  sorting nexin-31 isoform X5

  9. XM_017013156.1XP_016868645.1  sorting nexin-31 isoform X4

  10. XM_017013155.1XP_016868644.1  sorting nexin-31 isoform X3

  11. XM_017013154.1XP_016868643.1  sorting nexin-31 isoform X2

  12. XM_017013153.1XP_016868642.1  sorting nexin-31 isoform X1

  13. XM_017013163.1XP_016868652.1  sorting nexin-31 isoform X16

  14. XM_024447086.1XP_024302854.1  sorting nexin-31 isoform X15

    Conserved Domains (2) summary
    cl09511
    Location:22152
    FERM_B-lobe; FERM domain B-lobe
    cl17171
    Location:171247
    PH-like; Pleckstrin homology-like domain
  15. XM_024447084.1XP_024302852.1  sorting nexin-31 isoform X12

    Conserved Domains (2) summary
    cd13336
    Location:171285
    FERM-like_C_SNX31; Atypical FERM-like domain C-lobe of Sorting nexin 31
    cl09511
    Location:22152
    FERM_B-lobe; FERM domain B-lobe
  16. XM_017013165.1XP_016868654.1  sorting nexin-31 isoform X17

  17. XM_017013164.1XP_016868653.1  sorting nexin-31 isoform X17

RNA

  1. XR_001745488.1 RNA Sequence

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