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Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) [ Mus musculus (house mouse) ]

Gene ID: 16912, updated on 18-Apr-2024

Summary

Official Symbol
Psmb9provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)provided by MGI
Primary source
MGI:MGI:1346526
See related
Ensembl:ENSMUSG00000096727 AllianceGenome:MGI:1346526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmp2; Lmp-2; Ring12
Summary
Predicted to enable proteasome binding activity. Acts upstream of or within antigen processing and presentation and response to bacterium. Part of proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; and renal cell carcinoma. Orthologous to human PSMB9 (proteasome 20S subunit beta 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 97.4), thymus adult (RPKM 90.4) and 16 other tissues See more
Orthologs
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Genomic context

Location:
17 B1; 17 17.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34401006..34406347, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34182030..34187330, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1503 Neighboring gene STARR-positive B cell enhancer ABC_E1504 Neighboring gene histocompatibility 2, class II, locus Mb2 Neighboring gene STARR-positive B cell enhancer ABC_E7523 Neighboring gene histocompatibility 2, class II, locus Mb1 Neighboring gene STARR-positive B cell enhancer ABC_E11638 Neighboring gene STARR-positive B cell enhancer ABC_E1939 Neighboring gene STARR-seq mESC enhancer starr_42425 Neighboring gene transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34333284-34333657 Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spermatoproteasome complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-9
Names
LMP-2d
large multifunctional protease 2
low molecular mass protein 2
macropain chain 7
multicatalytic endopeptidase complex chain 7
proteasome chain 7
proteasome subunit beta-1i
proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
proteosome beta 9 subunit
really interesting new gene 12 protein
NP_001400133.1
NP_001400134.1
NP_001400135.1
NP_001400136.1
NP_001400137.1
NP_001400138.1
NP_001400140.1
NP_001400141.1
NP_038613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413204.1NP_001400133.1  proteasome subunit beta type-9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR974422
  2. NM_001413205.1NP_001400134.1  proteasome subunit beta type-9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974422
  3. NM_001413206.1NP_001400135.1  proteasome subunit beta type-9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974422
  4. NM_001413207.1NP_001400136.1  proteasome subunit beta type-9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974422
  5. NM_001413208.1NP_001400137.1  proteasome subunit beta type-9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CR974422
  6. NM_001413209.1NP_001400138.1  proteasome subunit beta type-9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CR974422
  7. NM_001413211.1NP_001400140.1  proteasome subunit beta type-9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CR974422
  8. NM_001413212.1NP_001400141.1  proteasome subunit beta type-9 isoform 6

    Status: VALIDATED

    Source sequence(s)
    CR974422
  9. NM_013585.3NP_038613.1  proteasome subunit beta type-9 isoform 1

    See identical proteins and their annotated locations for NP_038613.1

    Status: VALIDATED

    Source sequence(s)
    CR974422
    Consensus CDS
    CCDS28642.1
    UniProtKB/TrEMBL
    A0A0R4J256, Q3TAR7, Q3U7A7
    Related
    ENSMUSP00000133499.2, ENSMUST00000174576.4
    Conserved Domains (2) summary
    COG0638
    Location:13219
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03762
    Location:21207
    proteasome_beta_type_6; proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34401006..34406347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)