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Lmnb1 lamin B1 [ Mus musculus (house mouse) ]

Gene ID: 16906, updated on 18-Sep-2024

Summary

Official Symbol
Lmnb1provided by MGI
Official Full Name
lamin B1provided by MGI
Primary source
MGI:MGI:96795
See related
Ensembl:ENSMUSG00000024590 AllianceGenome:MGI:96795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables phospholipase binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in cellular response to monosodium L-glutamate. Located in nuclear inner membrane and nuclear lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Used to study adult-onset autosomal dominant demyelinating leukodystrophy. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 89.9), thymus adult (RPKM 41.9) and 17 other tissues See more
Orthologs
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Genomic context

See Lmnb1 in Genome Data Viewer
Location:
18 D3; 18 30.84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56840885..56886496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56707813..56753424)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 50288 Neighboring gene STARR-seq mESC enhancer starr_44668 Neighboring gene STARR-positive B cell enhancer ABC_E5662 Neighboring gene STARR-positive B cell enhancer ABC_E10992 Neighboring gene predicted gene, 41738 Neighboring gene STARR-seq mESC enhancer starr_44677 Neighboring gene membrane associated ring-CH-type finger 3 Neighboring gene predicted gene 15345 Neighboring gene VISTA enhancer mm109 Neighboring gene STARR-positive B cell enhancer ABC_E5663 Neighboring gene ribosomal protein S3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding NAS
Non-traceable Author Statement
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear lamina IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to L-glutamate ISO
Inferred from Sequence Orthology
more info
 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear pore localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of JNK cascade NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein localization to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in lamin filament IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear lamina IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nuclear lamina IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear lamina ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010721.2NP_034851.2  lamin-B1

    See identical proteins and their annotated locations for NP_034851.2

    Status: VALIDATED

    Source sequence(s)
    AK132252, BC052729
    Consensus CDS
    CCDS29261.1
    UniProtKB/Swiss-Prot
    P14733, Q61791
    Related
    ENSMUSP00000025486.9, ENSMUST00000025486.9
    Conserved Domains (2) summary
    pfam00038
    Location:32388
    Filament; Intermediate filament protein
    pfam00932
    Location:440544
    LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    56840885..56886496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)