Format

Send to:

Choose Destination

Lipg lipase, endothelial [ Mus musculus (house mouse) ]

Gene ID: 16891, updated on 8-Jul-2018
Official Symbol
Lipgprovided by MGI
Official Full Name
lipase, endothelialprovided by MGI
Primary source
MGI:MGI:1341803
See related
Ensembl:ENSMUSG00000053846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EL; mEDL; lipase; 3110013K01Rik
Expression
Biased expression in genital fat pad adult (RPKM 41.5), ovary adult (RPKM 21.2) and 10 other tissues See more
Orthologs
See Lipg in Genome Data Viewer
Location:
18; 18 E2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (74939322..74961263, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (75098976..75120917, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a, pseudogene 2 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial pseudogene Neighboring gene RIKEN cDNA 9030625G05 gene Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene ribosomal protein L17

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine 1-acylhydrolase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
triglyceride lipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
phospholipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of high-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
regulation of lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
endothelial lipase
Names
EDL
endothelial cell-derived lipase
lipose, endothelial
NP_034850.3
XP_006525755.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010720.3NP_034850.3  endothelial lipase precursor

    See identical proteins and their annotated locations for NP_034850.3

    Status: VALIDATED

    Source sequence(s)
    AK014047, AK150054, AK152161, AK152430, AK152872
    Consensus CDS
    CCDS29343.1
    UniProtKB/Swiss-Prot
    Q9WVG5
    UniProtKB/TrEMBL
    C0LQ91, Q3U5K0, Q3U713, Q3U807, Q3UDI6
    Related
    ENSMUSP00000066536.4, ENSMUST00000066532.4
    Conserved Domains (3) summary
    TIGR03230
    Location:51485
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:49340
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:347483
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    74939322..74961263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525692.2XP_006525755.1  endothelial lipase isoform X1

    Conserved Domains (2) summary
    cd00707
    Location:24271
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:278414
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
Support Center