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ZNF800 zinc finger protein 800 [ Homo sapiens (human) ]

Gene ID: 168850, updated on 3-Mar-2026
Official Symbol
ZNF800provided by HGNC
Official Full Name
zinc finger protein 800provided by HGNC
Primary source
HGNC:HGNC:27267
See related
Ensembl:ENSG00000048405 MIM:621007; AllianceGenome:HGNC:27267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within acinar cell differentiation and endocrine pancreas development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 4.8), testis (RPKM 2.3) and 25 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See ZNF800 in Genome Data Viewer
Location:
7q31.33
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (127342859..127392708, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (128654544..128706384, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127010097..127032762, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18590 Neighboring gene GRM8 antisense RNA 1 Neighboring gene PRELI domain containing 3B pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:127032217-127032717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26585 Neighboring gene uncharacterized LOC105375490 Neighboring gene long intergenic non-protein coding RNA 3012 Neighboring gene VISTA enhancer hs1308 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:127223080-127224279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127224999-127225998 Neighboring gene GRIP and coiled-coil domain containing 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Civelek M, et al. Am J Hum Genet, 2017 Mar 2. PMID 28257690, Free PMC Article
  2. Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation. Lin L, et al. Science, 2023 Oct 27. PMID 37883554
  3. Structured RNAs in the ENCODE selected regions of the human genome. Washietl S, et al. Genome Res, 2007 Jun. PMID 17568003, Free PMC Article
  4. Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination. Reich TR, et al. Cell Mol Life Sci, 2021 Jul. PMID 34100981, Free PMC Article
  5. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
    Title: Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ43301, MGC130032, MGC130033

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of enteroendocrine cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 800

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001438587.1 → NP_001425516.1  zinc finger protein 800 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC000123, AC000127

  2. NM_001438588.1 → NP_001425517.1  zinc finger protein 800 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC000123, AC000127

  3. NM_001438589.1 → NP_001425518.1  zinc finger protein 800 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC000123, AC000127

  4. NM_001438590.1 → NP_001425519.1  zinc finger protein 800 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC000123, AC000127

  5. NM_001438591.1 → NP_001425520.1  zinc finger protein 800 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC000123, AC000127

  6. NM_001438592.1 → NP_001425521.1  zinc finger protein 800 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC000127

  7. NM_001438593.1 → NP_001425522.1  zinc finger protein 800 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC000127

  8. NM_001438594.1 → NP_001425523.1  zinc finger protein 800 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC000127

  9. NM_001438595.1 → NP_001425524.1  zinc finger protein 800 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC000127

  10. NM_001438596.1 → NP_001425525.1  zinc finger protein 800 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC000127
    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0
    Related
    ENSP00000376988.1, ENST00000393312.5

  11. NM_001438597.1 → NP_001425526.1  zinc finger protein 800 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC000127
    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0
    Related
    ENSP00000638433.1, ENST00000968374.1

  12. NM_001438598.1 → NP_001425527.1  zinc finger protein 800 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC000127
    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0

  13. NM_001438599.1 → NP_001425528.1  zinc finger protein 800 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC000127
    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0

  14. NM_001438600.1 → NP_001425529.1  zinc finger protein 800 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC000127
    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0
    Related
    ENSP00000376989.1, ENST00000393313.5

  15. NM_001438601.1 → NP_001425530.1  zinc finger protein 800 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC000127

  16. NM_001438602.1 → NP_001425531.1  zinc finger protein 800 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC000127

  17. NM_001438603.1 → NP_001425532.1  zinc finger protein 800 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC000127

  18. NM_001438605.1 → NP_001425534.1  zinc finger protein 800 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC000127
    Related
    ENSP00000553785.1, ENST00000883726.1

  19. NM_001438606.1 → NP_001425535.1  zinc finger protein 800 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC000127
    UniProtKB/TrEMBL
    B7Z4V7

  20. NM_001438607.1 → NP_001425536.1  zinc finger protein 800 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC000127

  21. NM_001438608.1 → NP_001425537.1  zinc finger protein 800 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC000127

  22. NM_001438609.1 → NP_001425538.1  zinc finger protein 800 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC000127

  23. NM_001438610.1 → NP_001425539.1  zinc finger protein 800 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC000127

  24. NM_001438611.1 → NP_001425540.1  zinc finger protein 800 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC000123, AC000127

  25. NM_001438612.1 → NP_001425541.1  zinc finger protein 800 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC000127

  26. NM_001438613.1 → NP_001425542.1  zinc finger protein 800 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC000127

  27. NM_001438614.1 → NP_001425543.1  zinc finger protein 800 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC000127

  28. NM_001438615.1 → NP_001425544.1  zinc finger protein 800 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC000127

  29. NM_001438616.1 → NP_001425545.1  zinc finger protein 800 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC000127

  30. NM_001438617.1 → NP_001425546.1  zinc finger protein 800 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC000127

  31. NM_176814.5 → NP_789784.2  zinc finger protein 800 isoform 6

    See identical proteins and their annotated locations for NP_789784.2

    Status: VALIDATED

    Source sequence(s)
    AK309674, BC110623, BG112338, BU581251, DA888007
    Consensus CDS
    CCDS5795.1
    UniProtKB/Swiss-Prot
    Q2TB10, Q9HBN0
    Related
    ENSP00000265827.3, ENST00000265827.8
    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    127342859..127392708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515859.4 → XP_011514161.1  zinc finger protein 800 isoform X1

    See identical proteins and their annotated locations for XP_011514161.1

    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

  2. XM_047419942.1 → XP_047275898.1  zinc finger protein 800 isoform X2

  3. XM_006715868.5 → XP_006715931.1  zinc finger protein 800 isoform X1

    See identical proteins and their annotated locations for XP_006715931.1

    Conserved Domains (4) summary
    sd00019
    Location:488 → 508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:618 → 640
    zf-C2H2; Zinc finger, C2H2 type
    pfam16622
    Location:355 → 383
    zf-C2H2_11; zinc-finger C2H2-type
    pfam16624
    Location:391 → 485
    zf-C2H2_assoc2; Unstructured region upstream of a zinc-finger

  4. XM_047419941.1 → XP_047275897.1  zinc finger protein 800 isoform X1

  5. XM_047419949.1 → XP_047275905.1  zinc finger protein 800 isoform X6

  6. XM_047419946.1 → XP_047275902.1  zinc finger protein 800 isoform X4

  7. XM_047419945.1 → XP_047275901.1  zinc finger protein 800 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    128654544..128706384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357402.1 → XP_054213377.1  zinc finger protein 800 isoform X1

  2. XM_054357405.1 → XP_054213380.1  zinc finger protein 800 isoform X2

  3. XM_054357401.1 → XP_054213376.1  zinc finger protein 800 isoform X1

  4. XM_054357403.1 → XP_054213378.1  zinc finger protein 800 isoform X1

  5. XM_054357413.1 → XP_054213388.1  zinc finger protein 800 isoform X6

  6. XM_054357410.1 → XP_054213385.1  zinc finger protein 800 isoform X4

  7. XM_054357409.1 → XP_054213384.1  zinc finger protein 800 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TB10.1 GenPept UniProtKB/Swiss-Prot:Q2TB10

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