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Lifr LIF receptor alpha [ Mus musculus (house mouse) ]

Gene ID: 16880, updated on 8-Feb-2024

Summary

Official Symbol
Lifrprovided by MGI
Official Full Name
LIF receptor alphaprovided by MGI
Primary source
MGI:MGI:96788
See related
Ensembl:ENSMUSG00000054263 AllianceGenome:MGI:96788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIF; A230075M04Rik
Summary
Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and leukemia inhibitory factor receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Acts upstream of or within positive regulation of cell population proliferation. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study CAKUT. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 14.4), liver adult (RPKM 13.6) and 23 other tissues See more
Orthologs
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Genomic context

See Lifr in Genome Data Viewer
Location:
15 A1; 15 3.46 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (7120091..7226970)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (7090610..7197489)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30663 Neighboring gene STARR-seq mESC enhancer starr_37875 Neighboring gene STARR-seq mESC enhancer starr_37876 Neighboring gene predicted gene, 30971 Neighboring gene STARR-seq mESC enhancer starr_37878 Neighboring gene STARR-seq mESC enhancer starr_37880 Neighboring gene EGF-like, fibronectin type III and laminin G domains Neighboring gene FK506 binding protein 3 pseudogene Neighboring gene predicted gene, 41263 Neighboring gene predicted gene, 41262

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ciliary neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ciliary neurotrophic factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ciliary neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables leukemia inhibitory factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to oncostatin-M receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to oncostatin-M receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leukemia inhibitory factor receptor
Names
D-factor/LIF receptor
LIF-R
leukemia inhibitory factor receptor alpha chain
soluble differentiation-stimulating factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113386.1NP_001106857.1  leukemia inhibitory factor receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001106857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC104553, AK145864, BY716975
    Consensus CDS
    CCDS49577.1
    UniProtKB/TrEMBL
    Q3UKU5
    Related
    ENSMUSP00000131434.2, ENSMUST00000164529.9
    Conserved Domains (4) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:126239
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam18207
    Location:50124
    LIFR_N; Leukemia inhibitory factor receptor N-terminal domain
    cl21522
    Location:547613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001358593.1NP_001345522.1  leukemia inhibitory factor receptor isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC104553, AC158747
    Consensus CDS
    CCDS27369.1
    UniProtKB/Swiss-Prot
    P42703, Q5I0Y2
    UniProtKB/TrEMBL
    Q3U234
    Related
    ENSMUSP00000064551.6, ENSMUST00000067190.12
    Conserved Domains (4) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:126239
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam18207
    Location:50124
    LIFR_N; Leukemia inhibitory factor receptor N-terminal domain
    cl21522
    Location:547613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_013584.2NP_038612.1  leukemia inhibitory factor receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_038612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC104553, AC158747
    Consensus CDS
    CCDS27369.1
    UniProtKB/Swiss-Prot
    P42703, Q5I0Y2
    UniProtKB/TrEMBL
    Q3U234
    Related
    ENSMUSP00000154750.2, ENSMUST00000226471.2
    Conserved Domains (4) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:126239
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam18207
    Location:50124
    LIFR_N; Leukemia inhibitory factor receptor N-terminal domain
    cl21522
    Location:547613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    7120091..7226970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519969.4XP_006520032.1  leukemia inhibitory factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006520032.1

    UniProtKB/Swiss-Prot
    P42703, Q5I0Y2
    UniProtKB/TrEMBL
    Q3U234
    Conserved Domains (4) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:126239
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam18207
    Location:50124
    LIFR_N; Leukemia inhibitory factor receptor N-terminal domain
    cl21522
    Location:547613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_006519970.5XP_006520033.1  leukemia inhibitory factor receptor isoform X2

    See identical proteins and their annotated locations for XP_006520033.1

    UniProtKB/TrEMBL
    Q3UKU5
    Conserved Domains (4) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:126239
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam18207
    Location:50124
    LIFR_N; Leukemia inhibitory factor receptor N-terminal domain
    cl21522
    Location:547613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_006519971.2XP_006520034.1  leukemia inhibitory factor receptor isoform X2

    See identical proteins and their annotated locations for XP_006520034.1

    UniProtKB/TrEMBL
    Q3UKU5
    Related
    ENSMUSP00000154181.2, ENSMUST00000227727.2
    Conserved Domains (4) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:126239
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam18207
    Location:50124
    LIFR_N; Leukemia inhibitory factor receptor N-terminal domain
    cl21522
    Location:547613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_011245326.4XP_011243628.1  leukemia inhibitory factor receptor isoform X1

    See identical proteins and their annotated locations for XP_011243628.1

    UniProtKB/Swiss-Prot
    P42703, Q5I0Y2
    UniProtKB/TrEMBL
    Q3U234
    Conserved Domains (4) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam17971
    Location:126239
    LIFR_D2; Leukemia inhibitory factor receptor D2 domain
    pfam18207
    Location:50124
    LIFR_N; Leukemia inhibitory factor receptor N-terminal domain
    cl21522
    Location:547613
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...