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Lhx4 LIM homeobox protein 4 [ Mus musculus (house mouse) ]

Gene ID: 16872, updated on 26-Sep-2022

Summary

Official Symbol
Lhx4provided by MGI
Official Full Name
LIM homeobox protein 4provided by MGI
Primary source
MGI:MGI:101776
See related
Ensembl:ENSMUSG00000026468 AllianceGenome:MGI:101776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gsh4; Gsh-4; A330062J17Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; neuron differentiation; and placenta development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX4 (LIM homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Lhx4 in Genome Data Viewer
Location:
1 G3; 1 67.47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155573777..155627481, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155698031..155751726, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5532 Neighboring gene acyl-Coenzyme A binding domain containing 6 Neighboring gene quiescin Q6 sulfhydryl oxidase 1 Neighboring gene centrosomal protein 350 Neighboring gene predicted gene, 36934

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
LIM/homeobox protein Lhx4
Names
LIM homeo box protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010712.2NP_034842.2  LIM/homeobox protein Lhx4

    See identical proteins and their annotated locations for NP_034842.2

    Status: VALIDATED

    Source sequence(s)
    AC117598, BC049834
    Consensus CDS
    CCDS48399.1
    UniProtKB/Swiss-Prot
    P53776, Q9R280
    UniProtKB/TrEMBL
    A0A6P5Q0Z2, A0A8C6H6F9
    Related
    ENSMUSP00000027740.8, ENSMUST00000027740.14
    Conserved Domains (3) summary
    cd09376
    Location:89144
    LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family
    cd09468
    Location:3081
    LIM1_Lhx4; The first LIM domain of Lhx4
    pfam00046
    Location:160213
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    155573777..155627481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529169.3XP_006529232.1  LIM/homeobox protein Lhx4 isoform X1

    See identical proteins and their annotated locations for XP_006529232.1

    Conserved Domains (3) summary
    cd09376
    Location:2883
    LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family
    cl02475
    Location:120
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam00046
    Location:99153
    Homeobox; Homeobox domain