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Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Mus musculus (house mouse) ]

Gene ID: 16848, updated on 12-May-2024

Summary

Official Symbol
Lfngprovided by MGI
Official Full Name
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by MGI
Primary source
MGI:MGI:1095413
See related
Ensembl:ENSMUSG00000029570 AllianceGenome:MGI:1095413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in lymphocyte differentiation; negative regulation of Notch signaling pathway involved in somitogenesis; and somitogenesis. Acts upstream of or within several processes, including compartment pattern specification; positive regulation of Notch signaling pathway; and regulation of somitogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; inner ear; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 77.7), mammary gland adult (RPKM 72.5) and 25 other tissues See more
Orthologs
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Genomic context

See Lfng in Genome Data Viewer
Location:
5 G2; 5 79.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140593096..140601300)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140607341..140615545)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141043369-141043556 Neighboring gene STARR-positive B cell enhancer ABC_E8088 Neighboring gene galectin-related inter-fiber protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141072932-141073102 Neighboring gene predicted gene, 30603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141093710-141094027 Neighboring gene STARR-positive B cell enhancer ABC_E11729 Neighboring gene tweety family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6392 Neighboring gene IQ motif containing E Neighboring gene STARR-positive B cell enhancer ABC_E11307

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within compartment pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in marginal zone B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Notch signaling pathway involved in somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of somitogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Names
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
lunatic fringe
NP_032520.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008494.3NP_032520.1  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

    See identical proteins and their annotated locations for NP_032520.1

    Status: VALIDATED

    Source sequence(s)
    AK004642, AK153283, AW061165
    Consensus CDS
    CCDS19821.1
    UniProtKB/Swiss-Prot
    O09010, Q3U659, Q8K3F1, Q9DC10
    UniProtKB/TrEMBL
    B2RRW2
    Related
    ENSMUSP00000031555.2, ENSMUST00000031555.3
    Conserved Domains (1) summary
    pfam02434
    Location:109357
    Fringe; Fringe-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140593096..140601300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)