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Lepr leptin receptor [ Mus musculus (house mouse) ]

Gene ID: 16847, updated on 24-Jan-2023

Summary

Official Symbol
Leprprovided by MGI
Official Full Name
leptin receptorprovided by MGI
Primary source
MGI:MGI:104993
See related
Ensembl:ENSMUSG00000057722 AllianceGenome:MGI:104993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
Summary
Enables leptin receptor activity. Involved in several processes, including energy homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 5.0), placenta adult (RPKM 3.3) and 18 other tissues See more
Orthologs
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Genomic context

See Lepr in Genome Data Viewer
Location:
4 C6; 4 46.96 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101574393..101676375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101717137..101815352)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene leptin receptor overlapping transcript Neighboring gene PRAME like 17 Neighboring gene predicted gene, 52666

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105189

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables leptin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables leptin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bone growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycogen metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in leptin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of hydrolase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of locomotor rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to leptin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sexual reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
leptin receptor
Names
B219
LEP-R
OB receptor
leptin receptor gene-related protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122899.2NP_001116371.1  leptin receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001116371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 3' exon, as compared to variant 1. The resultign isoform (3) has a different and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL929373
    Consensus CDS
    CCDS51239.1
    UniProtKB/Swiss-Prot
    P48356
    UniProtKB/TrEMBL
    Q3US58, Q640Q2
    Related
    ENSMUSP00000102534.3, ENSMUST00000106921.9
    Conserved Domains (3) summary
    smart00060
    Location:737818
    FN3; Fibronectin type 3 domain
    cd00063
    Location:236328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:331418
    Lep_receptor_Ig; Ig-like C2-type domain
  2. NM_010704.2NP_034834.1  leptin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_034834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the 3' exon but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK143989, CN692760
    Consensus CDS
    CCDS18397.1
    UniProtKB/Swiss-Prot
    P48356
    UniProtKB/TrEMBL
    Q3UNU8
    Related
    ENSMUSP00000099838.4, ENSMUST00000102777.10
    Conserved Domains (3) summary
    smart00060
    Location:737818
    FN3; Fibronectin type 3 domain
    cd00063
    Location:236328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:331418
    Lep_receptor_Ig; Ig-like C2-type domain
  3. NM_146146.3NP_666258.2  leptin receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_666258.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL929373
    Consensus CDS
    CCDS51240.1
    UniProtKB/Swiss-Prot
    P48356, Q9QWV5
    Related
    ENSMUSP00000037385.4, ENSMUST00000037552.10
    Conserved Domains (3) summary
    smart00060
    Location:737818
    FN3; Fibronectin type 3 domain
    cd00063
    Location:236328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:331418
    Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101574393..101676375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163750.1XP_036019643.1  leptin receptor isoform X1

    Conserved Domains (4) summary
    smart00060
    Location:738819
    FN3; Fibronectin type 3 domain
    cd00063
    Location:237329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:328419
    Lep_receptor_Ig; Ig-like C2-type domain
    pfam18589
    Location:430532
    ObR_Ig; Obesity receptor immunoglobulin like domain
  2. XM_036163752.1XP_036019645.1  leptin receptor isoform X3

    Conserved Domains (4) summary
    smart00060
    Location:738819
    FN3; Fibronectin type 3 domain
    cd00063
    Location:237329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:328419
    Lep_receptor_Ig; Ig-like C2-type domain
    pfam18589
    Location:430532
    ObR_Ig; Obesity receptor immunoglobulin like domain
  3. XM_036163751.1XP_036019644.1  leptin receptor isoform X2

    Conserved Domains (4) summary
    smart00060
    Location:738819
    FN3; Fibronectin type 3 domain
    cd00063
    Location:237329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:328419
    Lep_receptor_Ig; Ig-like C2-type domain
    pfam18589
    Location:430532
    ObR_Ig; Obesity receptor immunoglobulin like domain