U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDC14C cell division cycle 14C [ Homo sapiens (human) ]

Gene ID: 168448, updated on 26-Oct-2022

Summary

Official Symbol
CDC14Cprovided by HGNC
Official Full Name
cell division cycle 14Cprovided by HGNC
Primary source
HGNC:HGNC:22427
See related
Ensembl:ENSG00000218305 AllianceGenome:HGNC:22427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC14B2; CDC14Bretro
Summary
This gene represents a retrogene of cell division cycle 14B (CDC14B), which is located on chromosome 9. The introns in the coding sequence have been processed out relative to the CDC14B locus, but there is an intact open reading frame that is missing only some sequence at the N-terminus, including the nuclear localiztion signal, relative to proteins encoded by the CDC14B gene. There is a difference in the subcellular localization of the protein encoded by this gene, relative to its parental gene product. While the parental gene product displays microtubular localization, GFP chimeras of the protein encoded by this gene localize to the endoplasmic reticulum, indicating a possible new functional role for this gene. [provided by RefSeq, Nov 2017]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CDC14C in Genome Data Viewer
Location:
7p12.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (48924547..48927454)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (49085418..49088324)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (48964143..48967050)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CDC14 cell division cycle 14 C-like Neighboring gene GDP dissociation inhibitor 2 pseudogene 1 Neighboring gene DEAD-box helicase 43 pseudogene 2 Neighboring gene uncharacterized LOC124901804

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC26484

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase CDC14C
Names
CDC14 cell division cycle 14 homolog C

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152627.3NP_689840.2  dual specificity protein phosphatase CDC14C

    Status: VALIDATED

    Source sequence(s)
    AC006024, BC028690, BC068452
    Consensus CDS
    CCDS94101.1
    UniProtKB/Swiss-Prot
    Q8NCT2
    Related
    ENSP00000497792.1, ENST00000650262.2
    Conserved Domains (2) summary
    pfam14671
    Location:22159
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:216330
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    48924547..48927454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    49085418..49088324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)