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RNF133 ring finger protein 133 [ Homo sapiens (human) ]

Gene ID: 168433, updated on 6-Nov-2022

Summary

Official Symbol
RNF133provided by HGNC
Official Full Name
ring finger protein 133provided by HGNC
Primary source
HGNC:HGNC:21154
See related
Ensembl:ENSG00000188050 AllianceGenome:HGNC:21154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See RNF133 in Genome Data Viewer
Location:
7q31.32
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (122697735..122699117, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (124013735..124015117, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (122337789..122339171, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene calcium dependent secretion activator 2 Neighboring gene uncharacterized LOC124901739 Neighboring gene uncharacterized LOC124901738 Neighboring gene ribosomal protein S26 pseudogene 31 Neighboring gene ring finger protein 148

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF133
Names
RING-type E3 ubiquitin transferase RNF133
NP_631914.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139175.2NP_631914.1  E3 ubiquitin-protein ligase RNF133 precursor

    See identical proteins and their annotated locations for NP_631914.1

    Status: REVIEWED

    Source sequence(s)
    BC022038
    Consensus CDS
    CCDS5784.1
    UniProtKB/Swiss-Prot
    Q8N7G7, Q8WVZ7
    Related
    ENSP00000344489.2, ENST00000340112.3
    Conserved Domains (2) summary
    cd02122
    Location:43177
    PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
    cl17238
    Location:254302
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    122697735..122699117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    124013735..124015117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)