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Ldhc lactate dehydrogenase C [ Mus musculus (house mouse) ]

Gene ID: 16833, updated on 1-Mar-2024

Summary

Official Symbol
Ldhcprovided by MGI
Official Full Name
lactate dehydrogenase Cprovided by MGI
Primary source
MGI:MGI:96764
See related
Ensembl:ENSMUSG00000030851 AllianceGenome:MGI:96764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ldh3; Ldh-3; Ldh-x; Ldhc4; LDH-C4
Summary
Enables L-lactate dehydrogenase activity. Acts upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate metabolic process. Located in cytoplasm and motile cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 1111.1) See more
Orthologs
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Genomic context

See Ldhc in Genome Data Viewer
Location:
7 B3; 7 30.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46510687..46527571)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46861263..46878147)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18874 Neighboring gene predicted gene 5331 Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-lactate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
L-lactate dehydrogenase C chain
Names
LDH testis subunit
LDH-C
lactate dehydrogenase 3, C chain, sperm specific
lactate dehydrogenase-X
NP_001355290.1
NP_001355291.1
NP_038608.1
XP_006540742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368361.1NP_001355290.1  L-lactate dehydrogenase C chain

    Status: VALIDATED

    Source sequence(s)
    AC090123
    Consensus CDS
    CCDS21290.1
    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases
  2. NM_001368362.1NP_001355291.1  L-lactate dehydrogenase C chain

    Status: VALIDATED

    Source sequence(s)
    AC090123
    Consensus CDS
    CCDS21290.1
    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases
  3. NM_013580.4NP_038608.1  L-lactate dehydrogenase C chain

    See identical proteins and their annotated locations for NP_038608.1

    Status: VALIDATED

    Source sequence(s)
    AC090123
    Consensus CDS
    CCDS21290.1
    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Related
    ENSMUSP00000014545.5, ENSMUST00000014545.11
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46510687..46527571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540679.1XP_006540742.1  L-lactate dehydrogenase C chain isoform X1

    See identical proteins and their annotated locations for XP_006540742.1

    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases