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Ldha lactate dehydrogenase A [ Mus musculus (house mouse) ]

Gene ID: 16828, updated on 27-Feb-2024

Summary

Official Symbol
Ldhaprovided by MGI
Official Full Name
lactate dehydrogenase Aprovided by MGI
Primary source
MGI:MGI:96759
See related
Ensembl:ENSMUSG00000063229 AllianceGenome:MGI:96759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ldh1; Ldhm; l7R2
Summary
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in liver E18 (RPKM 539.4), mammary gland adult (RPKM 508.1) and 28 other tissues See more
Orthologs
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Genomic context

See Ldha in Genome Data Viewer
Location:
7 B3; 7 30.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46491698..46505051)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46842274..46855627)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene general transcription factor II H, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_18872 Neighboring gene Rap1A-retro1 Neighboring gene STARR-seq mESC enhancer starr_18874 Neighboring gene predicted gene 5331 Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-lactate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables L-lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables lactate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of oxidoreductase complex ISO
Inferred from Sequence Orthology
more info
 
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
L-lactate dehydrogenase A chain
Names
LDH muscle subunit
LDH-M
M-LDH
lactate dehydrogenase 1, A chain
lactate dehydrogenase A4
NP_001129541.2
NP_034829.1
XP_030098036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136069.2NP_001129541.2  L-lactate dehydrogenase A chain isoform 2

    See identical proteins and their annotated locations for NP_001129541.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon that results in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK150156, BC094428, BY195537
    Consensus CDS
    CCDS52255.1
    UniProtKB/TrEMBL
    A0A1B0GSX0, Q3TCI7, Q3THB4, Q3TI99
    Related
    ENSMUSP00000148107.2, ENSMUST00000209984.2
    Conserved Domains (2) summary
    cd05293
    Location:48358
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:54353
    L-LDH-NAD; L-lactate dehydrogenase
  2. NM_010699.2NP_034829.1  L-lactate dehydrogenase A chain isoform 1

    See identical proteins and their annotated locations for NP_034829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AC090123, BC094428, BY227595
    Consensus CDS
    CCDS21289.1
    UniProtKB/Swiss-Prot
    P06151
    UniProtKB/TrEMBL
    G5E8N5, Q3TCI7, Q3THB4, Q3TI99, Q564E2
    Related
    ENSMUSP00000036386.10, ENSMUST00000048209.16
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases

RNA

  1. NR_102727.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK171373, AU079257, BC094428
    Related
    ENSMUST00000209548.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46491698..46505051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242176.1XP_030098036.1  L-lactate dehydrogenase A chain isoform X1

    UniProtKB/Swiss-Prot
    P06151
    UniProtKB/TrEMBL
    G5E8N5, Q3TCI7, Q3THB4, Q3TI99, Q564E2
    Conserved Domains (1) summary
    cd05293
    Location:19329
    LDH_1; A subgroup of L-lactate dehydrogenases