Format

Send to:

Choose Destination

Lcp2 lymphocyte cytosolic protein 2 [ Mus musculus (house mouse) ]

Gene ID: 16822, updated on 31-Jan-2019

Summary

Official Symbol
Lcp2provided by MGI
Official Full Name
lymphocyte cytosolic protein 2provided by MGI
Primary source
MGI:MGI:1321402
See related
Ensembl:ENSMUSG00000002699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
twm; SLP76; SLP-76; m1Khoe; AI323664; BB161688
Expression
Biased expression in thymus adult (RPKM 32.1), spleen adult (RPKM 12.0) and 7 other tissues See more
Orthologs

Genomic context

See Lcp2 in Genome Data Viewer
Location:
11; 11 A4
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (34047201..34092280)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (33947201..33992280)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene Kv channel-interacting protein 1 Neighboring gene predicted gene, 36395 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 1 Neighboring gene RIKEN cDNA 4930469K13 gene Neighboring gene predicted gene 12121 Neighboring gene forkhead box I1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cytokine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
TCR signalosome ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lymphocyte cytosolic protein 2
Names
SH2 domain-containing leukocyte protein of 76 kDa
SLP-76 tyrosine phosphoprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010696.4NP_034826.2  lymphocyte cytosolic protein 2

    See identical proteins and their annotated locations for NP_034826.2

    Status: VALIDATED

    Source sequence(s)
    AL645909
    Consensus CDS
    CCDS48768.1
    UniProtKB/Swiss-Prot
    Q60787
    Related
    ENSMUSP00000056621.5, ENSMUST00000052413.11
    Conserved Domains (3) summary
    cd09522
    Location:1078
    SAM_SLP76; SAM domain of SLP76 subfamily
    smart00454
    Location:1256
    SAM; Sterile alpha motif
    cd09929
    Location:411531
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    34047201..34092280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center