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Lcat lecithin cholesterol acyltransferase [ Mus musculus (house mouse) ]

Gene ID: 16816, updated on 27-Nov-2024

Summary

Official Symbol
Lcatprovided by MGI
Official Full Name
lecithin cholesterol acyltransferaseprovided by MGI
Primary source
MGI:MGI:96755
See related
Ensembl:ENSMUSG00000035237 AllianceGenome:MGI:96755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Wsu61e
Summary
Enables phosphatidylcholine-sterol O-acyltransferase activity and platelet-activating factor acetyltransferase activity. Involved in regulation of high-density lipoprotein particle assembly. Acts upstream of or within cholesterol metabolic process and lipoprotein biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Used to study Norum disease. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 395.2), liver E18 (RPKM 118.1) and 3 other tissues See more
Orthologs
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Genomic context

See Lcat in Genome Data Viewer
Location:
8 D3; 8 53.06 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106666183..106670034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105939551..105943402, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene chymotrypsin-like Neighboring gene proteasome (prosome, macropain) subunit, beta type 10 Neighboring gene solute carrier family 12, member 4 Neighboring gene microRNA 7074 Neighboring gene STARR-seq mESC enhancer starr_22546 Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in high-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of high-density lipoprotein particle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to copper ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in reverse cholesterol transport IEA
Inferred from Electronic Annotation
more info
 
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in very-low-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylcholine-sterol acyltransferase
Names
1-alkyl-2-acetylglycerophosphocholine esterase
PAF acetylhydrolase
lecithin-cholesterol acyltransferase Lcat
phospholipid-cholesterol acyltransferase
platelet-activating factor acetylhydrolase
NP_032516.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008490.2NP_032516.2  phosphatidylcholine-sterol acyltransferase precursor

    See identical proteins and their annotated locations for NP_032516.2

    Status: VALIDATED

    Source sequence(s)
    AI046659, AI574112, AK149476
    Consensus CDS
    CCDS22622.1
    UniProtKB/Swiss-Prot
    P16301, Q8K139
    UniProtKB/TrEMBL
    Q791M3
    Related
    ENSMUSP00000038232.8, ENSMUST00000038896.8
    Conserved Domains (1) summary
    cl21494
    Location:83408
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106666183..106670034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)