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Lat linker for activation of T cells [ Mus musculus (house mouse) ]

Gene ID: 16797, updated on 18-Sep-2024

Summary

Official Symbol
Latprovided by MGI
Official Full Name
linker for activation of T cellsprovided by MGI
Primary source
MGI:MGI:1342293
See related
Ensembl:ENSMUSG00000030742 AllianceGenome:MGI:1342293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pp36; p36-38
Summary
Predicted to enable protein kinase binding activity and signaling receptor complex adaptor activity. Acts upstream of or within gene expression; inflammatory response; and lymphocyte homeostasis. Located in cell-cell junction and immunological synapse. Part of COP9 signalosome. Is expressed in liver and thymus primordium. Used to study IgG4-related disease. Human ortholog(s) of this gene implicated in immunodeficiency 52. Orthologous to human LAT (linker for activation of T cells). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 497.8), spleen adult (RPKM 58.8) and 1 other tissue See more
Orthologs
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Genomic context

See Lat in Genome Data Viewer
Location:
7 F3; 7 69.01 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125962999..125968877, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126363827..126369705, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133500738-133500847 Neighboring gene predicted gene, 53206 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133513013-133513200 Neighboring gene microRNA 7058 Neighboring gene SPNS lysolipid transporter 1, lysophospholipid Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133521004-133521187 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein Neighboring gene STARR-seq mESC enhancer starr_20144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133540343-133540526

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular defense response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane raft distribution ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of TCR signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in immunological synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
linker for activation of T-cells family member 1
Names
36 kDa phospho-tyrosine adapter protein
36 kDa phosphotyrosine adapter protein
linker protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010689.3NP_034819.1  linker for activation of T-cells family member 1

    See identical proteins and their annotated locations for NP_034819.1

    Status: VALIDATED

    Source sequence(s)
    AC125322, AK134003, BE947351
    Consensus CDS
    CCDS21825.1
    UniProtKB/Swiss-Prot
    O54957
    UniProtKB/TrEMBL
    Q546H1, Q80UR6
    Related
    ENSMUSP00000032997.7, ENSMUST00000032997.8
    Conserved Domains (1) summary
    pfam15234
    Location:24242
    LAT; Linker for activation of T-cells

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    125962999..125968877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507396.3XP_006507459.3  linker for activation of T-cells family member 1 isoform X1

    Conserved Domains (1) summary
    pfam15234
    Location:137341
    LAT; Linker for activation of T-cells
  2. XM_006507398.5XP_006507461.1  linker for activation of T-cells family member 1 isoform X4

    Conserved Domains (1) summary
    pfam15234
    Location:8176
    LAT; Linker for activation of T-cells
  3. XM_006507397.4XP_006507460.2  linker for activation of T-cells family member 1 isoform X2

    UniProtKB/TrEMBL
    Q80UR6
    Conserved Domains (1) summary
    pfam15234
    Location:24224
    LAT; Linker for activation of T-cells
  4. XM_030242172.2XP_030098032.1  linker for activation of T-cells family member 1 isoform X3

    Conserved Domains (1) summary
    pfam15234
    Location:137281
    LAT; Linker for activation of T-cells