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OLIG3 oligodendrocyte transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 167826, updated on 8-Dec-2022

Summary

Official Symbol
OLIG3provided by HGNC
Official Full Name
oligodendrocyte transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:18003
See related
Ensembl:ENSG00000177468 MIM:609323; AllianceGenome:HGNC:18003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Bhlhb7; bHLHe20
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See OLIG3 in Genome Data Viewer
Location:
6q23.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (137492199..137494394, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (138680645..138682841, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137813336..137815531, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene FOXA motif-containing MPRA enhancer 183 Neighboring gene uncharacterized LOC102723633 Neighboring gene Sharpr-MPRA regulatory region 8938 Neighboring gene basic transcription factor 3 like 4 pseudogene 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
EBI GWAS Catalog
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
EBI GWAS Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord motor neuron migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
oligodendrocyte transcription factor 3
Names
class B basic helix-loop-helix protein 7
class E basic helix-loop-helix protein 20
oligo3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175747.2NP_786923.1  oligodendrocyte transcription factor 3

    See identical proteins and their annotated locations for NP_786923.1

    Status: VALIDATED

    Source sequence(s)
    AK096362
    Consensus CDS
    CCDS5186.1
    UniProtKB/Swiss-Prot
    Q7RTU3, Q8N8Q0
    Related
    ENSP00000356708.2, ENST00000367734.4
    Conserved Domains (1) summary
    pfam00010
    Location:85138
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    137492199..137494394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    138680645..138682841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)