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OLIG3 oligodendrocyte transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 167826, updated on 23-Nov-2021

Summary

Official Symbol
OLIG3provided by HGNC
Official Full Name
oligodendrocyte transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:18003
See related
Ensembl:ENSG00000177468 MIM:609323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Bhlhb7; bHLHe20
Orthologs
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Genomic context

See OLIG3 in Genome Data Viewer
Location:
6q23.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (137492199..137494394, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137813336..137815531, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986544 Neighboring gene FOXA motif-containing MPRA enhancer 183 Neighboring gene uncharacterized LOC102723633 Neighboring gene basic transcription factor 3 like 4 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 13388

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
GeneReviews: Not available
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
GeneReviews: Not available
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
GeneReviews: Not available
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord motor neuron migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
oligodendrocyte transcription factor 3
Names
class B basic helix-loop-helix protein 7
class E basic helix-loop-helix protein 20
oligo3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175747.2NP_786923.1  oligodendrocyte transcription factor 3

    See identical proteins and their annotated locations for NP_786923.1

    Status: VALIDATED

    Source sequence(s)
    AK096362
    Consensus CDS
    CCDS5186.1
    UniProtKB/Swiss-Prot
    Q7RTU3
    Related
    ENSP00000356708.2, ENST00000367734.4
    Conserved Domains (1) summary
    pfam00010
    Location:85138
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    137492199..137494394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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