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OLIG3 oligodendrocyte transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 167826, updated on 27-Nov-2024

Summary

Official Symbol
OLIG3provided by HGNC
Official Full Name
oligodendrocyte transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:18003
See related
Ensembl:ENSG00000177468 MIM:609323; AllianceGenome:HGNC:18003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Bhlhb7; bHLHe20
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See OLIG3 in Genome Data Viewer
Location:
6q23.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (137492199..137494394, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (138680645..138682841, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137813336..137815531, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378017 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137636227-137636827 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137672426-137672621 Neighboring gene FOXA motif-containing MPRA enhancer 183 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90385 Neighboring gene uncharacterized LOC102723633 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137744471-137745316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:137808523-137809198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137814441-137814940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:137816622-137817155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:137817156-137817688 Neighboring gene Sharpr-MPRA regulatory region 8938 Neighboring gene basic transcription factor 3 like 4 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25141 Neighboring gene Sharpr-MPRA regulatory region 13388 Neighboring gene OLIG3-TNFAIP3 interval homotypic cluster of transcription factor binding sites enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17585 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90442 Neighboring gene NANOG hESC enhancer GRCh37_chr6:137974082-137974598 Neighboring gene uncharacterized LOC105378018 Neighboring gene long intergenic non-protein coding RNA 3004

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
EBI GWAS Catalog
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
EBI GWAS Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord motor neuron migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
oligodendrocyte transcription factor 3
Names
class B basic helix-loop-helix protein 7
class E basic helix-loop-helix protein 20
oligo3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175747.2NP_786923.1  oligodendrocyte transcription factor 3

    See identical proteins and their annotated locations for NP_786923.1

    Status: VALIDATED

    Source sequence(s)
    AK096362
    Consensus CDS
    CCDS5186.1
    UniProtKB/Swiss-Prot
    Q7RTU3, Q8N8Q0
    Related
    ENSP00000356708.2, ENST00000367734.4
    Conserved Domains (1) summary
    pfam00010
    Location:85138
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    137492199..137494394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    138680645..138682841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)